Multiple regions of chromosome 6q affected by loss of heterozygosity in primary human breast carcinomas
| Autor: | Robert Callahan, M. Bistocchi, Antonio Marchetti, Z. M. Sheng, Fiamma Buttitta, Marie-Hélène Champème, Rosette Lidereau, Daniela Campani |
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| Rok vydání: | 1996 |
| Předmět: |
Cancer Research
medicine.medical_specialty Molecular Sequence Data Breast Neoplasms Locus (genetics) Biology Polymerase Chain Reaction Loss of heterozygosity Genetic linkage medicine Humans Genes Tumor Suppressor DNA Primers Sequence Tagged Sites Genetics Base Sequence Carcinoma Ductal Breast Cytogenetics Chromosome Mapping Molecular biology Gene Expression Regulation Neoplastic Chromosome 17 (human) Oncology Microsatellite Chromosomes Human Pair 6 Female Chromosome 21 Chromosome 22 Gene Deletion Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.1996.27 |
| Popis: | A total of 80 primary human breast carcinoma DNAs were analysed for loss of heterozygosity (LOH) on the long arm of chromosome 6, using microsatellite markers whose location has been defined physically and by linkage analysis. Loss of heterozygosity was observed in 38 of 80 (48%) tumours that were informative for at least one locus. The analysis revealed partial or interstitial deletions of chromosome 6q. Detailed mapping of chromosome 6q in these tumour DNAs identified two and perhaps three commonly deleted regions. One of these is located between markers D6S251 and D6S252 (6q14-q16.2), another between D6S268 and D6S261 (6q16.3-q23) and a third between D6S287 and D6S270 (6q22.3-q23.1). Images Figure 1 |
| Databáze: | OpenAIRE |
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