Effects of rs958804 and rs7858836 single‐nucleotide polymorphisms of the ASTN2 gene on pain‐related phenotypes in patients who underwent laparoscopic colectomy and mandibular sagittal split ramus osteotomy

Autor:	Tatsuya Ichinohe, Akira Kitamura, Rie Inoue, Hideyuki Nakagawa, Tsutomu Mieda, Kyoko Nakayama, Ken-ichi Fukuda, Daisuke Nishizawa, Hiroyuki Sumikura, Kazutaka Ikeda, Junko Hasegawa, Miki Tsujita, Masakazu Hayashida
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Male medicine.medical_specialty pain‐related phenotypes Osteotomy Sagittal Split Ramus Mandibular Osteotomy Single-nucleotide polymorphism Nerve Tissue Proteins Gastroenterology Polymorphism Single Nucleotide Fentanyl single nucleotide polymorphisms Internal medicine Genotype Clinical endpoint Medicine SNP Humans Pharmacology (medical) Allele laparoscopic colectomy Colectomy Aged Glycoproteins Pharmacology Pain Postoperative business.industry opioids Analgesia Patient-Controlled Original Articles Middle Aged Phenotype Analgesics Opioid Psychiatry and Mental health Clinical Psychology Opioid ASTN2 Original Article mandibular sagittal split ramus osteotomy Female Laparoscopy business medicine.drug
Zdroj:	Neuropsychopharmacology Reports
ISSN:	2574-173X
Popis:	Background Opioids are widely used as effective analgesics, but opioid sensitivity varies widely among individuals. The underlying genetic and nongenetic factors are not fully understood. Based on the results of our previous genome‐wide association study, we investigated the effects of single nucleotide polymorphisms (SNPs) of the astrotactin 2 (ASTN2) gene on pain‐related phenotypes in surgical patients. Methods We investigated the effects of two SNPs, rs958804 T/C and rs7858836 C/T, of the ASTN2 gene on eight and seven pain‐related phenotypes in 350 patients who underwent laparoscopic colectomy (LAC) and 358 patients who underwent mandibular sagittal split ramus osteotomy (SSRO), respectively. In both surgical groups, intravenous fentanyl patient‐controlled analgesia (PCA) was used for postoperative analgesia, and 24‐hour postoperative PCA fentanyl use was the primary endpoint. Results The association analyses among the two SNPs and pain‐related traits showed that 24‐hour fentanyl use was significantly associated with the two SNP genotypes in both surgical groups. The Mann‐Whitney test showed that 24‐hour fentanyl use was lower in patients with the C allele than in patients with the TT genotype of the rs958804 T/C SNP (P = .0019 and .0200 in LAC and SSRO patients, respectively), and it was lower in patients with the T allele than in patients with the CC genotype of the rs7858836 C/T SNP (P = .0017 and .0098 in LAC and SSRO patients, respectively). Conclusion The two SNPs of the ASTN2 gene were consistently associated with fentanyl requirements after two different types of surgery. These findings may contribute to personalized pain control. We investigated the effects of two SNPs, rs958804 T/C and rs7858836 C/T, which are located in the same LD block of the ASTN2 gene, on pain‐related phenotypes in two groups of patients who underwent laparoscopic colectomy and mandibular sagittal split ramus osteotomy. We found that these SNPs consistently reduced fentanyl requirements for postoperative analgesia, possibly by enhancing the analgesic effect of fentanyl.
Databáze:	OpenAIRE
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