Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications
| Autor: | Milena T. Pelegrino, Juliana S. Bernardes, L. C. Gonçalves, Paula S. Haddad, Daniele Ribeiro de Araujo, Amedea B. Seabra |
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| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
General Chemical Engineering Thermal decomposition Inorganic chemistry 02 engineering and technology General Chemistry Poloxamer 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry X-ray photoelectron spectroscopy Thiol Zeta potential Magnetic nanoparticles 0210 nano-technology Sodium nitrite Superparamagnetism Nuclear chemistry |
| Zdroj: | Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/c6ra28633j |
| Popis: | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Newton Advanced Fellowship (The Royal Society) Complexo Laboratorial Nanotecnologico (CLN) - UFABC - SisNano The present study is focused on the synthesis and characterization of nitric oxide (NO)-releasing superparamagnetic iron oxide nanoparticles (Fe3O4 NPs), and their incorporation in Pluronic F127 hydrogel with great potential for topical applications. Magnetite nanoparticles (Fe3O4 NPs) were synthesized by thermal decomposition of acetylacetonate iron (Fe(acac) 3), and coated with the thiol containing molecule mercaptosuccinic acid (MSA), leading to Fe3O4-MSA NPs. The obtained NPs were characterized using different techniques. The results showed that the Fe3O4-MSA NPs have a mean diameter of 11 nm, in the solid state, and superparamagnetic behavior at room temperature. Fe3O4-MSA NPs have an average hydrodynamic size of (78.0 +/- 0.9) nm, average size distribution (PDI) of 0.302 +/- 0.04, and zeta potential of (-22.10 +/- 0.55) mV. Free thiol groups on the Fe3O4-MSA NP surface were nitrosated by the addition of sodium nitrite, yielding S-nitrosated magnetic nanoparticles (Fe3O4-Snitroso-MSA NPs), which act as spontaneous NO donors upon S-N bond cleavage. The amount of (86.4 +/- 4.7) mmol of NO was released per gram of Fe3O4-S-nitroso-MSA NPs. In order to enhance NP dispersion, Fe3O4-MSA NPs were incorporated in Pluronic F127 hydrogel (3.4% w/w), and characterized using different techniques. Rheological measurements suggest a potential use for Fe3O4-MSA NPs dispersed in Pluronic hydrogel for topical applications. Atomic force microscopy (AFM) showed that the NPs are embedded within the Pluronic film while the X-ray photoelectron spectroscopy (XPS) spectrum of the Fe3O4-MSA NPs samples revealed the presence of iron, oxygen, carbon and sulfur, confirming the presence of MSA molecules on the NP surface. Univ Fed Sao Paulo, Exact & Earth Sci Dept, UNIFESP, Diadema, SP, Brazil Univ Fed ABC, Human & Nat Sci Ctr, Santo Andre, SP, Brazil CNPEM, Brazilian Ctr Res Energy & Mat, Campinas, SP, Brazil Exact and Earth Science Department, Universidade Federal de São Paulo, UNIFESP, Diadema, Brazil FAPESP: 2014/13913-7 FAPESP: 2016/10347-6 Newton Advanced Fellowship (The Royal Society): NA140046 SisNano: 402289/2013-7 Web of Science |
| Databáze: | OpenAIRE |
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