Reduced IL-1 production in adolescents with mite antigen asthma in remission
| Autor: | K. Aoki, Takeshi Noma, Kunio Ichikawa, Y Kawano, Yoshizawa I, Minoru Baba |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Lipopolysaccharides Male Cellular immunity Allergy Adolescent Immunology Peripheral blood mononuclear cell Monocytes Antigen immune system diseases Immunopathology medicine Animals Humans Immunology and Allergy Antigens Dermatophagoides Cells Cultured Glycoproteins Asthma Mites business.industry Remission Induction Respiratory disease medicine.disease respiratory tract diseases Female business Cell activation Interleukin-1 |
| Zdroj: | Clinical and Experimental Immunology. 113:10-16 |
| ISSN: | 1365-2249 0009-9104 |
| Popis: | To determine the immunological mechanisms associated with outgrowing mite antigen-induced bronchial asthma during adolescence, we studied the relationship between clinical status and Dermatophagoides farinae (Df) antigen-induced peripheral cell activation by measuring IL-1α and IL-lβ production in patients with bronchial asthma. After antigen-driven restimulation in vitro, there was increased IL-1α, IL-1β production by peripheral blood mononuclear cells (PBMC) from patients with active bronchial asthma, while cellular IL-1α, IL-1β production was reduced in patients with asthma in remission. IL-1α and IL-1β production by PBMC (possibly reflecting airway inflammation) after exposure to Df antigen might be down-regulated in patients outgrowing mite antigen-induced asthma, because lipopolysaccharide-induced IL-1α, IL-1β production (seen in both normal individuals and patients with active asthma) was also reduced when patients were in remission. |
| Databáze: | OpenAIRE |
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