A prospective, observational, multicentre study comparing tenecteplase facilitated PCI versus primary PCI in Indian patients with STEMI (STEPP-AMI)
| Autor: | Vijayakumar Subban, S. Selvamani, Ajit S. Mullasari, Bahuleyan C G, Suma M. Victor, A. Srinivas, Thomas Alexander |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment Cardiogenic shock Percutaneous coronary intervention Tenecteplase Context (language use) Coronary Artery Disease medicine.disease Surgery Clinical trial Internal medicine Conventional PCI medicine Clinical endpoint Myocardial infarction cardiovascular diseases Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Open Heart |
| ISSN: | 2053-3624 |
| Popis: | Objective To compare the efficacy of pharmacoinvasive strategy versus primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI). Primary PCI is the preferred treatment for STEMI, but it is not a feasible option for many. A pharmacoinvasive strategy might be a practical solution in the Indian context, although few empirical data exist to guide this approach. Methods This is a prospective, observational, multicentre pilot study. Two hundred consecutive patients with STEMI aged 18–75 years, presenting within 12 h of onset of symptoms and requiring a reperfusion strategy, were studied from five primary PCI capable centres in South India. Patients who opted for pharmacoinvasive strategy (n=45) formed group A. Group B consisted of patients treated with primary PCI (n=155). One patient was lost to follow-up at 1 year. The primary end point was a composite of death, cardiogenic shock, reinfarction, repeat revascularisation of a culprit artery and congestive heart failure at 30 days. Results The primary end point occurred in 11.1% in group A and in 3.9% in group B, p=0.07 (RR=2.87; 95% CI 0.92 to 8.97). The infarct-related artery patency at angiogram was 82.2% in group A and 22.6% in group B (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|