Direct assessment of the antioxidant property of salivary histatin
| Autor: | Tomoko Komatsu, Frank G. Oppenheim, Masaichi-Chang-il Lee, Kyo Kobayashi, Eva J. Helmerhorst |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Saliva antioxidant Antioxidant Radical medicine.medical_treatment Clinical Biochemistry Medicine (miscellaneous) medicine.disease_cause 03 medical and health sciences 0302 clinical medicine stomatognathic system medicine oxidative stress reactive oxygen species chemistry.chemical_classification saliva Reactive oxygen species 030109 nutrition & dietetics Nutrition and Dietetics histatin Antimicrobial Biochemistry chemistry Histatin Original Article 030211 gastroenterology & hepatology Oxidative stress Homeostasis |
| Zdroj: | Journal of Clinical Biochemistry and Nutrition |
| ISSN: | 1880-5086 0912-0009 |
| DOI: | 10.3164/jcbn.19-53 |
| Popis: | Histatin, a salivary protein, affects oral homeostasis through preservation of tooth integrity and protection against caries and fungal infections. However, the effects of histatin in the generation of oxidative stress induced by reactive oxygen species and in the oral cavity remain unclear. In this study, the effects of histatin on direct reactive oxygen species scavenging activity were examined using electron spin resonance. We demonstrated, for the first time, that histatin exhibits antioxidant activity against hydroxyl radicals generated by Fenton's reaction by metal chelation or binding. The direct antioxidant effects of histatin, along with its antimicrobial activity, may be important in the oral protection of salivary proteins. |
| Databáze: | OpenAIRE |
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