A Novel Mutation vf Causing Abnormal Vacuoles in the Central Nervous System Maps on Rat Chromosome 8
| Autor: | Birger Voigt, Toshihide Inui, Kazuhiro Kitada, Yoshifumi Nakane, Sumiko Kaji, Tamiko Adachi, Tadao Serikawa, Ken-ichi Yamasaki |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Central Nervous System
Cerebellum Genetic Linkage Red nucleus Mutant Central nervous system Vacuole Biology Reticular formation Rats Mutant Strains General Biochemistry Genetics and Molecular Biology Tremor medicine Animals Gene Crosses Genetic Genetics General Veterinary Chromosome Mapping General Medicine Spinal cord Molecular biology Rats Rats Inbred ACI Microscopy Electron medicine.anatomical_structure Mutation Vacuoles Animal Science and Zoology |
| Zdroj: | Experimental Animals. 51:149-155 |
| ISSN: | 1881-7122 1341-1357 |
| DOI: | 10.1538/expanim.51.149 |
| Popis: | Body-tremorous rats were found in a colony of WTC-tm rats and a new coisogenic mutant strain void of the tm mutation was established. Histological analysis revealed that these rat mutants had abnormal vacuoles in the red nucleus of the midbrain, the reticular formation in the brain stem, and the white matter of the cerebellum and spinal cord. Electron microscopic observation showed many irregular myelin-bound vacuoles and degenerated oligodendroglia. Genetic analysis indicated that the presence of the abnormal vacuoles in the central nervous system (CNS) is controlled by a recessive gene named "vacuole formation (vf)" on chromosome (Chr) 8, and that this gene is also involved in the appearance of body tremors. Comparative maps suggested that the mouse and human orthologs would be located on Chr 9 (43-48 cM) and Chr 6 (328-370 cR3000), respectively. Since similar mutations have not been mapped yet around these regions, the authors believe this novel rat mutation will allow the discovery of a new function of these particular genes that is involved in the development and maintenance of the CNS. |
| Databáze: | OpenAIRE |
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