Utilization pattern and survival outcomes of adjuvant therapies in high-grade nonretroperitoneal abdominal soft tissue sarcoma: A population-based study
| Autor: | Omar Mahmoud, Thomas F. DeLaney, William Ross Green, Ravi J. Chokshi, Salma K. Jabbour |
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| Rok vydání: | 2017 |
| Předmět: |
Oncology
Male medicine.medical_specialty Multivariate analysis Databases Factual medicine.medical_treatment Kaplan-Meier Estimate 03 medical and health sciences 0302 clinical medicine Internal medicine Adjuvant therapy Medicine Humans 030212 general & internal medicine Practice Patterns Physicians' Aged Proportional Hazards Models business.industry Proportional hazards model Soft tissue sarcoma Hazard ratio Age Factors Sarcoma General Medicine Middle Aged medicine.disease Confidence interval United States Surgery Radiation therapy Chemotherapy Adjuvant 030220 oncology & carcinogenesis Abdominal Neoplasms Propensity score matching Multivariate Analysis Female Radiotherapy Adjuvant Neoplasm Grading business |
| Zdroj: | Asia-Pacific journal of clinical oncology. 14(1) |
| ISSN: | 1743-7563 |
| Popis: | Background Nonretroperitoneal abdominal soft tissue sarcoma (NRA-STS) is a rare disease with limited data supporting its management. Our study aimed to reveal the utilization patterns of adjuvant therapy and its potential survival benefits using the National Cancer Data Base. Materials The analysis included patients with resected high-grade NRA-STS. Chi-square analysis was used to evaluate distribution of patient and tumor-related factors within treatment groups. The Kaplan–Meier and Cox proportional hazards model were utilized to evaluate overall survival according to treatment approach. Multivariate analysis was used to determine the impact of these factors on patients’ outcome. Matched propensity score analysis was implemented to control for imbalance of confounding variables. Results At median follow-up of 49 months, 5-year overall survival improved from 46% without adjuvant radiation therapy to 52% (P = 0.009) with radiotherapy delivery with a 30% reduction in hazard of death (95% confidence interval = 0.58–0.84). On multivariate analysis, age |
| Databáze: | OpenAIRE |
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