Viruses in activated by mustard (bis(chloroethyl) sulfide) as vaccines
| Autor: | Carl Tenbroeck, Roger M. Herriott |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
viruses
Formaldehyde Biology Sulfides medicine.disease_cause General Biochemistry Genetics and Molecular Biology Virus Microbiology chemistry.chemical_compound Immunity Mustard Gas medicine Humans Tyrosine Vaccines Rabies virus medicine.disease Cholera Virology Hydrocarbons Mustard Plant chemistry Vaccines Inactivated Viruses Rabies |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 62(2) |
| ISSN: | 0037-9727 |
| Popis: | For some years we have been using the rapidly advancing knowledge of protein chemistry in an attempt to find an agent other than formaldehyde that would inactivate viruses without destroying their anti-genic nature. Formaldehyde reacts primarily with amino groups of protein but it also attacks other radicals. While some formal-inized virus preparations are good immunizing agents many are not satisfactory, perhaps because the virus is not present in sufficient quantity. Reagents known to react with amino, tyrosine phenol, or SH groups of protein and several detergents have been used with disappointing results. Either the virus was not completely inactivated or else it failed to immunize animals to the active virus. It has been shown that mustard (Cl— CH2—CH2)2—S reacts with proteins1 and it is our purpose here to report the tests we have made on the effect of this chemical on a number of viruses.Eastern equine encephalomyelitis virus, fixed rabies virus, and hog cholera virus have been treated with chemica... |
| Databáze: | OpenAIRE |
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