Finger millet arabinoxylan protects mice from high-fat diet induced lipid derangements, inflammation, endotoxemia and gut bacterial dysbiosis
| Autor: | Mahendra Bishnoi, Ravneet K. Boparai, Dhirendra Pratap Singh, Siddhartha M. Sarma, Shashank K. Singh, Kanthi Kiran Kondepudi, Vandana Bijalwan, Pragyanshu Khare, Koushik Mazumder, Shrikant Mantri, Kamlesh K. Bhutani, Priyanka Mangal, Paramdeep Singh, Jaspreet Kaur |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Adipose Tissue White Inflammation White adipose tissue Biology Diet High-Fat Polysaccharide Biochemistry Eleusine Mice 03 medical and health sciences chemistry.chemical_compound Cecum Structural Biology Internal medicine Adipocyte medicine Animals Humans Molecular Biology chemistry.chemical_classification 030109 nutrition & dietetics medicine.diagnostic_test Body Weight food and beverages General Medicine Glucose Tolerance Test Lipid Metabolism medicine.disease Endotoxemia Gastrointestinal Microbiome Endocrinology medicine.anatomical_structure Gene Expression Regulation Liver chemistry Dysbiosis Xylans medicine.symptom Lipid profile Weight gain |
| Zdroj: | International Journal of Biological Macromolecules. 106:994-1003 |
| ISSN: | 0141-8130 |
| Popis: | Arabinoxylan (AX), a non-starch polysaccharide extracted from cereals such as wheat, rice and millets, is known to impart various health promoting effects. Our earlier study suggested that finger millet (FM) could ameliorate high fat diet (HFD)-induced metabolic derangements. The present study is aimed to evaluate the effect of FM-AX supplementation, a key bioactive from finger millet, on HFD-induced metabolic and gut bacterial derangements. Male Swiss albino mice were fed with normal chow diet (NPD) or HFD (60%kcal from fat) for 10 weeks. FM-AX was orally supplemented at doses of 0.5 and 1.0g/kg bodyweight on every alternate day for 10 weeks. Glucose tolerance, serum hormones, hepatic lipid accumulation and inflammation, white adipose tissue marker gene expression, adipocyte size and inflammation; metagenomic alterations in cecal bacteria; cecal short chain fatty acids and colonic tight junction gene expressions were studied. FM-AX supplementation prevented HFD-induced weight gain, alerted glucose tolerance and serum lipid profile, hepatic lipid accumulation and inflammation. Hepatic and white adipose tissue gene expressions were beneficially modulated. Further, AX supplementation prevented metagenomic alterations in cecum; improved ileal and colonic health and overall prevented metabolic endotoxemia. Present work suggests that AX from finger millet can be developed as a nutraceutical for the management of HFD- induced obesity. |
| Databáze: | OpenAIRE |
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