A novel nucleoside from the edible mushroom, Tricholoma japonicum

Autor:	Miyuki Fukai, Kaoru Kinoshita, Kiyotaka Koyama, Akane Haraguchi
Rok vydání:	2015
Předmět:	chemistry.chemical_classification Stereochemistry Tricholoma japonicum Tricholoma Glycoside Biology Adenosine Uridine Umbilical vein Edible mushroom chemistry.chemical_compound chemistry Biochemistry medicine Molecular Medicine Sugar N-Glycosyl Hydrolases Nucleoside medicine.drug
Zdroj:	Journal of Natural Medicines. 69:584-588
ISSN:	1861-0293 1340-3443
DOI:	10.1007/s11418-015-0917-5
Popis:	A novel nucleoside, 9-β-D-ribopyranosylpurine (2), along with three known nucleosides, adenosine (1), uridine (3) and nebularine (4), were isolated from the edible mushroom, Tricholoma japonicum. The structure of 2 was determined as 9-β-D-ribopyranosylpurine by comparing the reported spectral data of 2 with that of a synthetic compound. Isolation of the glycoside, which contains the sugar ribopyranose, from natural resources is very unusual. There are reports on the synthesis of 9-β-D-ribopyranosylpurine (2), but this is the first report on the isolation from natural resources. The antiproliferative activity of compounds 1-4 was evaluated using human umbilical vein endothelial cells. Compound 4 showed the highest inhibitory activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9416e198c224838661625af3b009016d https://doi.org/10.1007/s11418-015-0917-5 Zobrazit plný text záznamu Full text from SpringerLink