Proteose intoxications and body protein injury

Autor:	J. V. Cooke, G. H. Whipple
Rok vydání:	1916
Předmět:	Base line medicine.medical_specialty Chemistry Antithrombin Cell injury General Biochemistry Genetics and Molecular Biology Surgery Urinary nitrogen chemistry.chemical_compound Endocrinology Blood pressure Internal medicine medicine Proteose medicine.drug
Zdroj:	Experimental Biology and Medicine. 14:45-47
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-14-28
Popis:	Proteose injections in dogs cause well-known clinical reactions—vomiting, diarrhea, temperature reactions, low blood pressure, prostration and after large doses, an excess of antithrombin with incoagulable blood. A single proteose injection—for example one half a lethal dose—causes abrupt clinical reactions in a normal dog with apparent complete recovery within 24 to 48 hours. The nitrogen elimination curve in a fasting dog under such conditions shows a great rise in total urinary nitrogen. The apex of the curve usually falls on the second 24-hour period following the injection. This rise may be over 100 per cent. increase above the mean base line nitrogen level. It does not fall promptly to normal but declines slowly in 3 to 5 days or more toward the original base line. This speaks for a definite cell injury with destruction of considerable protein substance due to a single proteose injection. The disturbance of cell equilibrium is not rapidly nor promptly restored to normal.A dog which has received prev...
Databáze:	OpenAIRE
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