The psoas muscle transversal diameter predicts mortality in patients with cirrhosis on a waiting list for liver transplantation: A retrospective cohort study

Autor: Pauline Houssel Debry, Audrey Huguet, Karim Boudjema, Michel Rayar, Edouard Bardou Jacquet, Caroline Jezequel, Marianne Latournerie, Dominique Guyader, L. Legros, Ronan Thibault
Přispěvatelé: CHU Pontchaillou [Rennes], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Institut National de la Recherche Agronomique (INRA)-Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Rok vydání: 2018
Předmět:
Liver Cirrhosis
Male
Sarcopenia
medicine.medical_specialty
Cirrhosis
Waiting Lists
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Liver transplantation
Sensitivity and Specificity
Computed tomography scan
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
medicine
Humans
Body Weights and Measures
In patient
Correlation test
10. No inequality
Psoas Muscles
Retrospective Studies
Liver graft
2. Zero hunger
Nutrition and Dietetics
Receiver operating characteristic
business.industry
Malnutrition
Liver failure
Reproducibility of Results
Muscle mass
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Retrospective cohort study
Middle Aged
medicine.disease
Confidence interval
Liver Transplantation
3. Good health
Waiting list
030220 oncology & carcinogenesis
Feasibility Studies
Female
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
030211 gastroenterology & hepatology
Radiology
Tomography
X-Ray Computed
business
Zdroj: Nutrition
Nutrition, Elsevier, 2018, 51-52, pp.73-79. ⟨10.1016/j.nut.2018.01.008⟩
Nutrition, 2018, 51-52, pp.73-79. ⟨10.1016/j.nut.2018.01.008⟩
ISSN: 0899-9007
Popis: International audience; Objective Malnutrition impairs prognosis in liver cirrhosis. Our aims were to determine (1) if transversal (TPTI) and axial (APTI) psoas thickness indices predict mortality in cirrhotic patients and (2) the feasibility and reproducibility of transversal (TDPM) and axial (ADPM) diameters of the psoas muscle measurements.Methods This was a retrospective study. Inclusion criteria included cirrhosis diagnosis, on liver transplantation waiting list, and abdominal computed tomography (CT) scan within the 3 mo preceding list inscription. TDPM and ADPM were measured on a single umbilicus-targeted CT image by non-expert and expert operators. TPTI or APTI (mm/m) were calculated as TDPM or ADPM/height (m). Area under the receiver operating characteristic curve (AUC) and Cox proportional hazard models were assessed. TPTI and APTI interobserver agreement κ correlation test.Results A total of 173 patients were included. Low TPTI was associated with increased mortality AUC = 0.66 (95% confidence interval, 0.51–0.80). TPTI was the only factor associated with mortality (hazard ratio = 0.87, 95% confidence interval 0.76–0.99, P = 0.034). There was an almost perfect interobserver agreement between the two operators TDPM, κ = 0.97; ADPM, κ = 0.94; P < 0.0001.Conclusions TPTI measured on umbilicus-targeted CT scan before inscription on the waiting list for liver transplantation predicts mortality of cirrhotic patients. TPTI measurement is easy and reliable, even by a non-trained operator, and this is highly feasible in daily clinical practice.
Databáze: OpenAIRE
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