Combined radiotherapy and chemotherapy versus radiotherapy alone in elderly patients with nasopharyngeal carcinoma
| Autor: | Zhenfu Fu, Haitao Jiang, Yangming Jiang, Zhimin Ye, Fangzheng Wang, Fengqin Yan, Yongfeng Piao, Yan Lu, Chuner Jiang, Jianfeng Hua |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Oncology medicine.medical_specialty Multivariate analysis medicine.medical_treatment Observational Study chemotherapy radiation therapy survival Cohort Studies Drug Therapy Internal medicine otorhinolaryngologic diseases Humans Medicine Stage (cooking) Aged Proportional Hazards Models Retrospective Studies Aged 80 and over Radiotherapy business.industry Proportional hazards model nasopharyngeal carcinoma Nasopharyngeal Neoplasms Retrospective cohort study General Medicine medicine.disease SEER Radiation therapy Nasopharyngeal carcinoma Geriatrics Propensity score matching Cohort Female business SEER Program Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Currently, the impact of chemotherapy (CT) on survival outcomes in elderly patients with nasopharyngeal carcinoma (NPC) receiving radiation therapy (RT) remains controversial. This retrospective study aims to investigate survival outcomes in a cohort of elderly NPC patients receiving RT alone or together with CT. Clinical data on 529 NPC patients aged 65 years and older extracted from the Surveillance, Epidemiology, and End Results registry (2004–2015) was collected and retrospectively reviewed. In this cohort, 74 patients were treated with RT alone and 455 individuals received RT and CT. We used propensity score matching with a 1:3 ratio to identify correlations between patients based on 6 different variables. Kaplan–Meier analysis was used to evaluate overall (OS) and cancer-specific survival (CSS). The differences in OS and CSS between the 2 treatment groups were compared using the Log-rank test and Cox proportional hazards models. The estimated 5-year OS and CSS rates for all patients were 49.5% and 59.3%, respectively. The combination of RT and CT provided longer OS than RT alone (53.7% vs 36.9%, P = .002), while no significant difference was observed in CSS (61.8% vs 51.7%, P = .074) between the 2 groups. Moreover, multivariate analysis demonstrated that the combination of CT and RT correlated favorably with OS and CSS. Subgroup analyses showed that the combination of RT and CT correlated better with both OS and CSS in patients with stage T3 or N2 or stage III. Among NPC patients aged 65 years and older, treatment with RT and CT provided longer OS than RT alone. Furthermore, the combination of RT and CT showed a better correlation with OS and CSS in NPC patients with stage T3 or N2 or stage III. |
| Databáze: | OpenAIRE |
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