Intersystem Extrapolation Factors Are Substrate-Dependent for CYP3A4: Impact on Cytochrome P450 Reaction Phenotyping

Autor:	Alyssa L. Dantonio, Angela C. Doran, R. Scott Obach
Rok vydání:	2021
Předmět:	Cytochrome P-450 CYP2C19 Pharmacology Cytochrome P-450 CYP2D6 Cytochrome P-450 Enzyme System Microsomes Liver Cytochrome P-450 CYP3A Humans Pharmaceutical Science Recombinant Proteins
Zdroj:	Drug Metabolism and Disposition. 50:249-257
ISSN:	1521-009X 0090-9556
DOI:	10.1124/dmd.121.000758
Popis:	The use of intersystem extrapolation factors (ISEF) is required for the quantitative scaling of drug metabolism data generated in individually expressed cytochrome P450 (CYP) enzymes when estimating fractional contribution (f
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941225e19aefe188cfbb733507d966d3 https://doi.org/10.1124/dmd.121.000758 Zobrazit plný text záznamu