Merkel cell polyomavirus is a passenger virus in both poroma and porocarcinoma
| Autor: | Anna-Stiina Meriläinen, Virve Koljonen, Harri Sihto |
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| Přispěvatelé: | Department of Pathology, Medicum, Department of Surgery, HUS Musculoskeletal and Plastic Surgery, Plastiikkakirurgian yksikkö |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty TISSUES Histology CARCINOMA Adolescent Merkel cell polyomavirus Dermatology medicine.disease_cause Pathology and Forensic Medicine 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Poroma Antigen INFECTION medicine Carcinoma Humans Child poroma Aged Aged 80 and over T-ANTIGEN Polyomavirus Infections biology Merkel cell carcinoma HUMAN-PAPILLOMAVIRUS Eccrine Porocarcinoma Middle Aged biology.organism_classification medicine.disease 3. Good health Passenger virus Carcinoma Merkel Cell Sweat Gland Neoplasms Tumor Virus Infections 030220 oncology & carcinogenesis Female 3111 Biomedicine Carcinogenesis Immunostaining |
| Zdroj: | Journal of cutaneous pathologyREFERENCES. 49(1) |
| ISSN: | 1600-0560 |
| Popis: | Background Merkel cell polyomavirus (MCPyV) has been studied in several malignant and nonmalignant tissues. However, only in Merkel cell carcinoma (MCC) has the connection to tumorigenesis been established. Previously, eccrine porocarcinoma samples were shown to express MCPyV in the majority of samples. We aimed to examine MCPyV in porocarcinoma and poroma samples using MCC as the reference material. Methods We analyzed 17 porocarcinoma and 50 poroma samples for the presence of MCPyV using LT antigen immunostaining and DNA detection methods. In addition, 180 MCC samples served as controls. Results MCPyV LT antigen immunostaining was detected in 10% of poroma and 18% of porocarcinoma samples; on the other hand, it was present in 65% of MCC samples. MCPyV DNA was detected in only 10% of poroma and porocarcinoma samples compared with 96% of MCC samples. The viral DNA copy number in all MCPyV DNA-positive MCCs was at least 25 times higher than that in porocarcinoma or poroma samples with the highest MCPyV DNA-to-PTPRG ratio. Conclusions The low number of viral DNA copies in poroma and porocarcinoma samples, together with the negative LT expression of MCPyV DNA-positive tumors, indicates that MCPyV is simply a passenger virus rather than an oncogenic driver of porocarcinoma. |
| Databáze: | OpenAIRE |
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