Use of an Emollient As a Steroid-Sparing Agent in the Treatment of Mild to Moderate Atopic Dermatitis in Children
| Autor: | D B S Alan Leach, Peter M. Laskarzewski, Anne W. Lucky, Horst Wenck |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
Allergy medicine.medical_specialty Adolescent Hydrocortisone medicine.drug_class Topical Corticosteroid Therapy Administration Topical Anti-Inflammatory Agents Dermatology Dermatitis Atopic Atopy Pharmacotherapy Humans Medicine Single-Blind Method Child Emollients business.industry Atopic dermatitis medicine.disease Regimen Child Preschool Pediatrics Perinatology and Child Health Corticosteroid Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Pediatric Dermatology. 14:321-324 |
| ISSN: | 1525-1470 0736-8046 |
| DOI: | 10.1111/j.1525-1470.1997.tb00968.x |
| Popis: | The effectiveness of an emollient as an adjunct to topical corticosteroid therapy for the treatment of mild to moderate atopic dermatitis was studied for 3 weeks in 25 children 3 to 15 years of age in comparison with corticosteroid therapy alone. The adjunctive regimen of a once-daily application each of hydrocortisone 2.5% cream and of a water-in-oil cream was equivalent in efficacy to the comparative regimen of twice-daily applications of hydrocortisone 2.5% cream. Both treatment regimens elicited significant improvement in skin condition by day 7 ( p0.005) and further significant improvement by day 14 (p0.005). No significant differences between the two treatment regimens were observed in the rates of improvement (p0.545) or in the reductions in mean lesion size (p0.98). No differences were observed in parental evaluations, except for ease of application where a slight preference was expressed for the hydrocortisone 2.5% cream preparation (p0.038). We conclude that emollient adjunctive therapy offers a steroid-sparing alternative to topical corticosteroids alone in the treatment of mild to moderate atopic dermatitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text