Antitumor response against myeloma cells by immunization with mouse syngenic dendritoma
| Autor: | M.-G. Gobert, Alberto Roseto, S. Quéant, J. Kadouche, C.-O. Sarde |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.drug_class
T cell Immunology Biology Monoclonal antibody Cancer Vaccines Mice Immune system medicine Immunology and Allergy Animals Cytotoxicity Mice Inbred BALB C Hybridomas Antitumor response Dendritic Cells Microscopy Electron medicine.anatomical_structure Immunization Cell culture Cancer research Syngenic Multiple Myeloma Cell Division T-Lymphocytes Cytotoxic |
| Zdroj: | Hybridoma (2005). 24(4) |
| ISSN: | 1554-0014 |
| Popis: | In order to generate an immune response against myeloma cells in an homogenous murine model, a stable hybrid cell line (DCSp) was established through the syngenic fusion between mouse dendritic cells (DC) and mouse Sp2/0 myeloma cells. DCSp cells behaved as potent T cell stimulators and were able to induce Sp2/0 specific cytotoxicity. When mice were immunized with irradiated hybrids before SP2/0 injection, they exhibited a significantly higher rate of survival as compared with controls. When tumors were detected, their emergence was not delayed, and time elapsed between tumor clinical perception and death remained unchanged. A humoral immune response was also always associated. We assume that this stable dendritoma cell line can be considered a valuable tool for myeloma studies in an homogenous mouse model. The efficiency of dendritoma as a weapon against tumor cells and the benefit of syngeny in experimental models are discussed. |
| Databáze: | OpenAIRE |
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