Interferon increases HLA synthesis in melanoma cells: interferon-resistant and -sensitive cell lines
| Autor: | Teresa Y. Basham, M. F. Bourgeade, Abla A. Creasey, Thomas C. Merigan |
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| Rok vydání: | 1982 |
| Předmět: |
Time Factors
Cell division Human leukocyte antigen Biology Cell Line Antigen HLA Antigens Interferon Viral Interference medicine Humans Fibroblast Melanoma Multidisciplinary Neoplasms Experimental Cell cycle medicine.disease Virology medicine.anatomical_structure Gene Expression Regulation Cell culture Cancer research Interferons beta 2-Microglobulin Cell Division Research Article medicine.drug |
| Zdroj: | Proceedings of the National Academy of Sciences. 79:3265-3269 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.79.10.3265 |
| Popis: | We report that human leukocyte interferon preparations increase the expression of beta 2-microglobulin by 100-200% on the surface of normal fibroblast and melanoma cell lines sensitive to interferon. This increase in expression can be correlated with an increase in HLA synthesis as measured by incorporation of [35S]methionine in these antigens. This enhanced HLA synthesis, which is 5- to 17-fold, is time dependent and dose related. Synchronized cells in the G0/G1 phase of the cell cycle appear to be more sensitive to this interferon action. Neither an increase in surface expression nor in HLA synthesis is observed in a melanoma cell line resistant to the antiviral and antigrowth effects of interferon. Furthermore, there appears to be a stronger correlation between this increased HLA synthesis and the antiviral function than between it and the antiproliferative action of interferon. |
| Databáze: | OpenAIRE |
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