Immunohistochemical Expression and Serum Levels of CD44 as Prognostic Indicators in Patients with Non-Small Cell Lung Cancer
| Autor: | Tomoko So, Soichi Oka, Hidetaka Uramoto, Masaru Takenaka, Takeshi Hanagiri, Sohsuke Yamada, Akihiro Taira, Shinji Shinohara, Yasuhiro Chikaishi, Fumihiro Tanaka |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology Cancer Research medicine.medical_specialty Lung Neoplasms Enzyme-Linked Immunosorbent Assay Malignancy 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Carcinoma Non-Small-Cell Lung Internal medicine Biomarkers Tumor medicine Carcinoma Humans Clinical significance Stage (cooking) Lung cancer Aged Neoplasm Staging Aged 80 and over biology business.industry CD44 General Medicine Middle Aged Prognosis medicine.disease Immunohistochemistry Up-Regulation Gene Expression Regulation Neoplastic Hyaluronan Receptors 030104 developmental biology 030220 oncology & carcinogenesis Predictive value of tests biology.protein Female business |
| Zdroj: | Oncology. 90:327-338 |
| ISSN: | 1423-0232 0030-2414 |
| Popis: | Background/Objectives: CD44 is often expressed in various types of tumor cells and involved in a number of biological behaviors of malignancy. The present study focused on the clinical significance of the expression of CD44st and CD44v6 in non-small cell lung cancer (NSCLC). Methods: The cohort consisted of 261 consecutive patients who had undergone complete resection of NSCLC. CD44 expression was evaluated in surgical specimens by immunohistochemical staining. Serum CD44 levels were determined using a sandwich ELISA (enzyme-linked immunosorbent assay). Results: In the immunohistochemical analysis, significant correlations were observed between CD44 expression and clinicopathological factors such as the T factor, N factor, pathological stage, and histological type. The 5-year survival rates according to CD44v6 expression were 65.8 and 80.6% in the higher and lower expression groups, respectively (p = 0.0053). According to ELISA, the group with higher expression of serum CD44v6 also showed a significantly more unfavorable prognosis than the lower expression group (p = 0.014). According to multivariate analysis using these significant variables, serum CD44v6 level was found to be an independent prognostic factor (p = 0.048). Conclusions: CD44v6 overexpression and higher serum CD44v6 levels were found to be significantly unfavorable prognostic factors. |
| Databáze: | OpenAIRE |
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