Evaluation of prooxidant-antioxidant balance in chronic heroin users in a single assay: an identification criterion for antioxidant supplementation
| Autor: | Theodora Papamitsou, Kakia Nikolaou, Konstantina Topouridou, George Koliakos, Leda Kovatsi, Samuel Njau |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Antioxidant medicine.medical_treatment Medicine (miscellaneous) Pharmacology medicine.disease_cause Antioxidants Heroin Young Adult Medicine Humans Young adult Psychiatry biology Greece business.industry Heroin Dependence Case-control study Hepatitis C Antibodies medicine.disease Oxidants Substance abuse Analgesics Opioid Psychiatry and Mental health Clinical Psychology Oxidative Stress Case-Control Studies biology.protein Antibody Opiate business Oxidative stress medicine.drug |
| Zdroj: | The American journal of drug and alcohol abuse. 36(4) |
| ISSN: | 1097-9891 |
| Popis: | Background: Opiate abuse has been linked to oxidative stress, through the separate evaluation of oxidants and antioxidants. Objectives: To determine prooxidant–antioxidant balance (PAB) in chronic heroin users in a single assay, easily applied in a clinical setting. Specifically, to examine whether PAB values correlate with the duration of abuse or with the presence of anti-HCV antibodies. Methods: Sixty-four chronic heroin users - 34 cases and 30 controls - participated in this study. PAB was determined by an Enzyme-linked immunosorbent assay (ELISA) method, developed by members of the study group. Results: In heroin users, oxidative balance was disrupted in favor of prooxidants. There was no correlation of PAB values with the duration of abuse or with the presence of anti-Hepatitis C virus (HCV) antibodies. Conclusions: Chronic heroin users can benefit from an antioxidant therapy, and the method currently presented can be used as an identification criterion. |
| Databáze: | OpenAIRE |
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