HLA alleles associated with asparaginase hypersensitivity in Chinese children
| Autor: | Yu-Lung Lau, Alan Kwok Shing Chiang, Daniel Ka Leung Cheuk, Alex Wing Kwan Leung, Wing Leung, Marco Ho, Shau Yin Ha, Ian C. K. Wong, Janette Kwok, Godfrey Chi-Fung Chan, P Ip, Wai Keung Chu, Jaime S. Rosa Duque, Chun Wing Luk, Alvin Siu-Cheung Ling, Wilfred Hing Sang Wong, Y.S. Chan, Gilbert T. Chua, Chi Kong Li, Anthony P.Y. Liu, Pamela P. W. Lee, Mike Yat Wah Kwan, Oscar Kuen Fong Yiu |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Asparaginase Allergy China Antineoplastic Agents Human leukocyte antigen Gastroenterology Drug Hypersensitivity chemistry.chemical_compound Asian People HLA Antigens Internal medicine medicine Hypersensitivity Humans Genetic Predisposition to Disease Diseases of the blood and blood-forming organs Allele Child Molecular Biology Letter to the Editor Children B cell Alleles RC254-282 Retrospective Studies Hematology Chinese business.industry Lymphoma Non-Hodgkin Neoplasms. Tumors. Oncology. Including cancer and carcinogens Retrospective cohort study Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Lymphoma Human leukocyte antigens medicine.anatomical_structure Oncology chemistry Child Preschool Female RC633-647.5 business |
| Zdroj: | Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-4 (2021) Journal of Hematology & Oncology |
| ISSN: | 1756-8722 |
| Popis: | Asparaginase is an important drug to treat childhood haematological malignancies. Data on the association between human leukocyte antigens (HLA) and asparaginase hypersensitivity among Chinese are lacking. We conducted a retrospective study to identify HLA alleles associated with asparaginase hypersensitivity among Chinese children with acute lymphoblastic leukaemia (ALL), mixed phenotype leukaemia and non-Hodgkin lymphoma (NHL), who received asparaginases with HLA typing performed between 2009 and 2019. 107 Chinese patients were analysed. 66.3% (71/107) developed hypersensitivity to at least one of the asparaginases. HLA-B*46:01 (OR 3.8, 95% CI 1.4–10.1, p p l-asparaginase hypersensitivities, which remained significant after adjustment for age, gender and B cell ALL [HLA-B*46:01 (adjusted OR 3.5, 95% 1.3–10.5, p = 0.02) and DRB1*09:01 (OR 4.4, 95% CI 1.6–13.3, p |
| Databáze: | OpenAIRE |
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