Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma

Autor: Silvia Adriana López de Blanc, Rosana Andrea Morelatto, Daniel Piccini, Natalia Guiñazú, María-Elina Itoiz, Susana Gea
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
Pathology
Nitric Oxide Synthase Type II
medicine.disease_cause
chemistry.chemical_compound
Field cancerization
Medicine
Nitrite
Mouth neoplasm
Aged
80 and over
biology
medicine.diagnostic_test
Carcinoma oral de células escamosas
Nitric oxide synthase 2
Patología
purl.org/becyt/ford/3.1 [https]
Middle Aged
CIENCIAS MÉDICAS [UNESCO]
Ciencias de la salud
Medicina Básica
Oral squamous cell carcinoma
UNESCO::CIENCIAS MÉDICAS
Carcinoma
Squamous Cell
Immunohistochemistry
Female
Mouth Neoplasms
purl.org/becyt/ford/3 [https]
Adult
medicine.medical_specialty
CIENCIAS MÉDICAS Y DE LA SALUD
Odontología
Biopsy
parasitic diseases
Carcinoma
Humans
Nitric Oxide Synthase 2 (NOS2)
Cancerización de campo
General Dentistry
Aged
Marcadores de malignidad
Oral Medicine and Pathology
business.industry
Research
medicine.disease
stomatognathic diseases
Cross-Sectional Studies
Otorhinolaryngology
chemistry
biology.protein
Surgery
business
Carcinogenesis
Malignity markers
Zdroj: Repositorio Digital Universitario (UNC)
Universidad Nacional de Córdoba
instacron:UNC
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Medicina Oral, Patología Oral y Cirugía Bucal
Morelatto, Rosana ; Itoiz, María-Elina ; Guiñazú, Natalia ; Piccini, Daniel ; Gea, Susana ; López de Blanc, Silvia Adriana. Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2014, Vol. 19, No. 3: 242-247
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname
Popis: The activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcinomas, which is considered a model to study field cancerization. The aim of the present study is to analyze NOS2 expression at the histologically normal margins of OSCC. Study Design: Eleven biopsy specimens of OSCC containing histologically normal margins (HNM) were analyzed. Ten biopsies of normal oral mucosa were used as controls. The activity of NOS2 was determined by immunohistochemistry. Salivary nitrate and nitrite as well as tobacco and alcohol consumption were also analyzed. The Chi-squared test was applied. Results: Six out of the eleven HNM from carcinoma samples showed positive NOS2 activity whereas all the control group samples yielded negative (p=0.005). No statistically significant association between enzyme expression and tobacco and/or alcohol consumption and salivary nitrate and nitrite was found. Conclusion: NOS2 expression would be an additional evidence of alterations that may occur in a state of field cancerization before the appearance of potentially malignant morphological changes. Fil: Morelatto, Rosana Andrea. Universidad Nacional de Córdoba; Argentina Fil: Itoiz, María Elina. Universidad de Buenos Aires; Argentina Fil: Guiñazu Alaniz, Natalia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energias Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energias Alternativas; Argentina Fil: Piccini, Daniel. Universidad Nacional de Córdoba; Argentina Fil: Gea, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina Fil: Lopez de Blanc, Silvia Adriana. Universidad Nacional de Córdoba; Argentina
Databáze: OpenAIRE
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