Urine Toxicology as an Outcome Measure in Drug Abuse Clinical Trials
| Autor: | Donald R. Wesson, Peggy Compton, Walter Ling, V. C. Charuvastra, Jeffery N. Wilkins |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Narcotics medicine.medical_specialty Substance-Related Disorders Sample (material) Medicine (miscellaneous) Urine Pharmacotherapy Internal medicine Urine toxicology medicine Humans business.industry General Medicine Middle Aged medicine.disease Buprenorphine Surgery Analgesics Opioid Substance abuse Clinical trial Psychiatry and Mental health Clinical Psychology Female business Methadone medicine.drug |
| Zdroj: | Journal of Addictive Diseases. 15:85-92 |
| ISSN: | 1545-0848 1055-0887 |
| DOI: | 10.1300/j069v15n02_07 |
| Popis: | Clinical trials designed to establish the effectiveness of a pharmacotherapy for the treatment of drug abuse typically call for the collection and analysis of three urine samples per week to detect changes in drug use patterns. Examination of over 16,500 urine samples collected from 225 subjects during a one year buprenorphine/methadone clinical trial indicates that analysis of one weekly urine sample from those collected on a three-times-per-week fixed schedule provides essentially the same outcome information as analysis of all three weekly urines. Further, the percent of opiate-positive samples is constant across weekday, indicating that a single urine, randomly selected from those collected each week, is a valid indicator of treatment performance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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