Imaging of head and neck tumors with positron emission tomography and [11C]methionine
| Autor: | Heikki Joensuu, Eeva Nordman, Sirkku Leskinen-Kallio, Maria Lapela, Paula Lindholm |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Lymphoma Pleomorphic adenoma chemistry.chemical_compound Methionine Positron medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Carbon Radioisotopes Aged Lymphoepithelioma Aged 80 and over Radiation medicine.diagnostic_test business.industry Middle Aged medicine.disease Transitional cell carcinoma Oncology chemistry Head and Neck Neoplasms Positron emission tomography Carcinoma Squamous Cell Adenocarcinoma Female business Nuclear medicine Tomography Emission-Computed |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 30:1195-1199 |
| ISSN: | 0360-3016 |
| Popis: | Purpose: To evaluate the value of positron emission tomography and [ 11 C]methionine in imaging of malignant tumors of the head and neck region. Methods and Materials: Forty-seven tumors of the head and neck were investigated with 11 C-labeled methionine and positron emission tomography before treatment. Because of the resolution limits of the positron emission tomography scanner, all tumors selected for the study were larger than 1 cm in diameter. Results: Forty-two (91%) of the 46 malignant tumors were clearly visible in the positron emission tomography image (squamous cell carcinoma, n = 26; lymphoma, n = 9; adenocystic carcinoma, n = 2; lymphoepithelioma, n = 1; adenocarcinoma, n = 1; transitional cell carcinoma, n = 1; esthesioneuroblastoma, n = 1; plasmocytoma, n =1), while three (7%) squamous cell carcinomas were visible, but less easy to detect due to physiological accumulation of the tracer in the area under observation. Only one (2%) squamous cell carcinoma could not be delineated from the positron emission tomography image, and there was no uptake of ( 11 C]methionine in a benign pleomorphic adenoma. No correlation was found between the uptake of [ 11 C]methionine and the histological grade in the subset of squamous cell carcinoma ( n = 30). High physiological uptake of [ 11 C]methionine was observed in the salivary glands and the bone marrow. Conclusions: Malignant head and neck tumors can be effectively imaged with positron emission tomography using [ 11 C]methionine as the tracer. |
| Databáze: | OpenAIRE |
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