Effect of microbial siderophores on mammalian non-malignant and malignant cell lines
Autor: | Karuna Gokarn, Ramprasad B. Pal, Vishwas Sarangdhar |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Siderophore Pathology medicine.medical_specialty Exochelin-MS Siderophores Mycobactin Deferoxamine Peptides Cyclic Deferoxamine B Mice 03 medical and health sciences 0302 clinical medicine Cell Line Tumor Animals Humans Medicine Malignant cells MTT assay Oxazoles Cell Proliferation business.industry Cell growth Cancer Mycobactin S General Medicine medicine.disease 030104 developmental biology Complementary and alternative medicine Biochemistry 030220 oncology & carcinogenesis business Research Article Mammalian cell lines medicine.drug |
Zdroj: | BMC Complementary and Alternative Medicine |
ISSN: | 1472-6882 |
DOI: | 10.1186/s12906-017-1657-8 |
Popis: | Background Iron is a vital nutrient for all cells, and malignant cells have a higher requirement for the metal due to their rapid multiplication. Bacterial siderophores can be used to reduce free ferric ion concentration from the cellular environment. Methods In the present study, we have evaluated effect of three siderophores – exochelin-MS, mycobactin S and deferoxamine B on the proliferation of mammalian cell lines using MTT assay. Results These siderophores caused a significant decrease in the viability of malignant cells, without significantly affecting non-malignant cells. Conclusions Based on these results, we suggest that iron-chelation therapy could be explored as an adjunctive therapeutic option against cancer along with other therapies. |
Databáze: | OpenAIRE |
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