Acute and subacute (28-Day) toxicity studies of ionic liquid, didecyldimethyl ammonium acesulfamate, in rats

Autor:	Michał Nowicki, Aneta Konwerska, Małgorzata Kujawska, Jadwiga Jodynis-Liebert, Ewelina Petzke, Teresa Adamska, Juliusz Pernak, Małgorzata Ewertowska, Danuta Ostalska-Nowicka
Rok vydání:	2009
Předmět:	medicine.medical_specialty Health Toxicology and Mutagenesis Administration Oral Ionic Liquids Blood Pressure Hematocrit Toxicology Rats Sprague-Dawley Eating chemistry.chemical_compound Internal medicine Parenchyma medicine Animals Ammonium Rats Wistar Mean platelet volume Mean corpuscular volume Pharmacology Chemical Health and Safety Hematology Dose-Response Relationship Drug medicine.diagnostic_test Public Health Environmental and Occupational Health General Medicine Acute toxicity Rats Oxonic Acid Endocrinology chemistry Biochemistry Toxicity Female
Zdroj:	Drug and Chemical Toxicology. 32:395-404
ISSN:	1525-6014 0148-0545
DOI:	10.1080/01480540902976929
Popis:	The aim of this study was to investigate acute and subacute oral toxicity of an ionic liquid, didecyldimethylammonium acesulfamate [DDA][Ace], in rats. The compound tested was classified to the fourth toxicity class with a fixed LD(50) cut-off value of 500 mg/kg. Organ pathology induced by [DDA][Ace] in acute experiments included exfoliation of the surface layer of the digestive tract and alveolar septa in lung parenchyma. In a subacute experiment, rats were administered 10, 50, and 100 mg/kg/day [DDA][Ace] for 28 days. Reduced body weight gain and reduced food consumption was observed in mid- and high-dose rats. Statistically significant hematology changes were found mostly in high-dose groups of both sexes: increases in hematocrit, mean corpuscular volume, and mean platelet volume. Statistically significant changes in clinical chemistry parameters included increases in the GGT, SDH, and LDH activity and bilirubin concentration, and decreases in triglycerides, glucose, and inorganic phosphorus concentration. No treatment-related microscopic changes were observed. Under the conditions of this study, the lowest-observed-adverse-effect level of [DDA][Ace] was considered to be 10 mg/kg/day.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9406f5cf5fe1b67175ef01396ea31656 https://doi.org/10.1080/01480540902976929 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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