A 4-[(3R,4R)-dihydroxypyrrolidino]pyrimidin-2-one nucleobase for a CG base pair in triplex DNA
| Autor: | Masaaki Akabane, Motoi Nakahara, Yuri Hatanaka, Satoshi Obika, Yoshiyuki Hari |
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| Rok vydání: | 2011 |
| Předmět: |
Base Sequence
Base pair Chemistry Stereochemistry Triplex DNA Metals and Alloys DNA Pyrimidinones General Chemistry Nucleic Acid Denaturation Catalysis Substrate Specificity Surfaces Coatings and Films Electronic Optical and Magnetic Materials Nucleobase Oligodeoxyribonucleotides Materials Chemistry Ceramics and Composites Transition Temperature Base Pairing |
| Zdroj: | Chemical Communications. 47:4424 |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/c1cc10138b |
| Popis: | In order to expand target sequences in triplex DNA formation, the development of a nucleobase that recognizes a CG base pair in dsDNA was attempted. A 4-[(3R,4R)-dihydroxypyrrolidino]pyrimidin-2-one nucleobase was found to recognize a CG base pair with high sequence-selectivity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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