Core-in-cup/liquisol dual tackling effect on azelnidipine buccoadhesive tablet micromeritics, in vitro release, and mucoadhesive strength

Autor: Amira A. Rashad, Omaima N. El-Gazayerly, Sara Nageeb El-Helaly, Randa T. Abd El Rehim
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Dihydropyridines
core-in-cup
Polymers
Azelnidipine
in vitro release
Acrylic Resins
Biological Availability
Pharmaceutical Science
02 engineering and technology
030226 pharmacology & pharmacy
03 medical and health sciences
Granulation
azelnidipine
Drug Delivery Systems
0302 clinical medicine
Adhesives
medicine
Mucoadhesion
Cellulose
Pharmaceutical industry
Pharmacology
Chitosan
Chemistry
liquisol
Mouth Mucosa
Administration
Buccal
General Medicine
Factorial experiment
021001 nanoscience & nanotechnology
Micromeritics
Bioavailability
Carboxymethyl cellulose
tablet micromeritics
Solubility
buccoadhesive tablets
Carboxymethylcellulose Sodium
Delayed-Action Preparations
Drug delivery
azelnidipine
liquisol
HD9665-9675
0210 nano-technology
Azetidinecarboxylic Acid
Tablets
medicine.drug
Nuclear chemistry
Zdroj: Acta Pharmaceutica, Vol 69, Iss 3, Pp 381-398 (2019)
Acta Pharmaceutica
Volume 69
Issue 3
ISSN: 1846-9558
1330-0075
Popis: Reduced bioavailability of azelnidipine is related to its poor aqueous solubility and extensive first-pass metabolism, which hinder its efficacy. These problems were addressed by implementing (1) a liquisol technique for promoting the dissolution rate in a controlled-release manner and (2) a core-in-cup bucco-adhesive drug delivery system as an alternative to the oral route. A 33 factorial design was used to study the effects of polymer type (sodium carboxymethyl cellulose (CMC Na), chitosan, or Carbomer P940) concentration (5, 10 or 15 %) and preparation technique (simple mix, liquisol or wet granulation) on the dissolution and mucoadhesion of core-in-cup azelnidipine buccoadhesive tablets. Tablet micromeritics, swelling index, mucoadhesive strength and in vitro release were characterized. Statistical analyses of these factors show ed significant effects on the studied responses, where F#16 prepared by the liquisol technique and containing 15 % CMC Na was chosen with an overall desirability of 0.953.
Databáze: OpenAIRE
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