Electrophysiological Correlates of Rodent Default-Mode Network Suppression Revealed by Large-Scale Local Field Potential Recordings
| Autor: | Miranda J. Francoeur, Sidharth Hulyalkar, Jyoti Mishra, Nathalie Buscher, Dhakshin S. Ramanathan, Leila Fakhraei, Tianzhi Tang, Pragathi Priyadharsini Balasubramani |
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| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
medicine.diagnostic_test Posterior parietal cortex Local field potential Biology Electroencephalography Temporal lobe 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Cortex (anatomy) Posterior cingulate medicine General Earth and Planetary Sciences Original Article Functional magnetic resonance imaging Neuroscience human activities 030217 neurology & neurosurgery Default mode network 030304 developmental biology General Environmental Science |
| Zdroj: | Cereb Cortex Commun |
| ISSN: | 2632-7376 |
| Popis: | The default-mode network (DMN) in humans consists of a set of brain regions that, as measured with functional magnetic resonance imaging (fMRI), show both intrinsic correlations with each other and suppression during externally oriented tasks. Resting-state fMRI studies have previously identified similar patterns of intrinsic correlations in overlapping brain regions in rodents (A29C/posterior cingulate cortex, parietal cortex, and medial temporal lobe structures). However, due to challenges with performing rodent behavior in an MRI machine, it is still unclear whether activity in rodent DMN regions are suppressed during externally oriented visual tasks. Using distributed local field potential measurements in rats, we have discovered that activity in DMN brain regions noted above show task-related suppression during an externally oriented visual task at alpha and low beta-frequencies. Interestingly, this suppression (particularly in posterior cingulate cortex) was linked with improved performance on the task. Using electroencephalography recordings from a similar task in humans, we identified a similar suppression of activity in posterior cingulate cortex at alpha/low beta-frequencies. Thus, we have identified a common electrophysiological marker of DMN suppression in both rodents and humans. This observation paves the way for future studies using rodents to probe circuit-level functioning of DMN function. Significance Here we show that alpha/beta frequency oscillations in rats show key features of DMN activity, including intrinsic correlations between DMN brain regions, task-related suppression, and interference with attention/decision-making. We found similar task-related suppression at alpha/low beta-frequencies of DMN activity in humans. |
| Databáze: | OpenAIRE |
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