Regulation by thyroid status of c-myc, c-fos and H-ras mRNAs in the rat myocardium
| Autor: | Michael C. Sheppard, Jayne A. Franklyn, M. D. Gammage, N K Green |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Thyroid Gland c-Fos Proto-Oncogene Proteins c-myc Proto-Oncogene Proteins p21(ras) Transduction (genetics) Endocrinology Hypothyroidism Proto-Oncogene Proteins Internal medicine Gene expression medicine Animals Euthyroid RNA Messenger Gene Messenger RNA biology Thyroid Heart Rats Inbred Strains Blotting Northern Rats medicine.anatomical_structure Gene Expression Regulation biology.protein Triiodothyronine Female Proto-Oncogene Proteins c-fos Intracellular |
| Zdroj: | Journal of Endocrinology. 130:239-244 |
| ISSN: | 1479-6805 0022-0795 |
| DOI: | 10.1677/joe.0.1300239 |
| Popis: | Effects of thyroid status on expression of a variety of myocardial genes, such as those encoding contractile proteins, have been reported, as well as interactions between thyroid hormones and developmental and haemodynamic regulation of contractile protein synthesis. In addition, it is clear that developmental and haemodynamic factors regulate expression of specific proto-oncogenes, including c-myc, c-fos and H-ras, in the myocardium but the effect of thyroid status on such proto-oncogene products, which are proposed to play a critical signal-transducing role in the heart, has been previously unexplored. In order to determine whether changes in thyroid status are associated with changes in expression of these putative intracellular signals, we examined the effect of hypothyroidism and tri-iodothyronine (T3) treatment on myocardial levels of c-myc, c-fos and H-ras mRNAs in the rat. The induction of hypothyroidism was associated with a marked increase in myocardial c-myc, c-fos and H-ras mRNAs, changes reversed by 72 h of T3 replacement. Administration of T3 to euthyroid rats had no significant effect on myocardial c-myc or c-fos mRNAs, but inhibition of H-ras mRNA by T3 was evident. These observations demonstrating influences of thyroid status on expression of specific proto-oncogenes suggest that thyroid hormones, as well as exerting direct effects on expression of functionally important myocardial genes, also interact with the cellular transduction pathways mediated by the products of the c-myc, c-fos and H-ras genes. Journal of Endocrinology (1991) 130, 239–244 |
| Databáze: | OpenAIRE |
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