Differences in cytokine levels between the nasal polyps of adolescents with local allergic and adolescents with allergic or nonallergic rhinitis
| Autor: | Joo-Hwa Kim, Jin Hyeok Jeong, Ha-Na Kang, Youngjin Choi, Jae-Won Oh |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Allergy Nasal Provocation Tests Adolescent medicine.medical_treatment Immunoglobulin E medicine.disease_cause Nasal provocation test Young Adult 03 medical and health sciences Nasal Polyps 0302 clinical medicine Nonallergic rhinitis medicine Humans Immunology and Allergy Nasal polyps Child 030223 otorhinolaryngology Rhinitis Eosinophil cationic protein biology business.industry Interleukin General Medicine Allergens medicine.disease Rhinitis Allergic Eosinophils 030228 respiratory system Immunology Allergic response biology.protein Cytokines Female business |
| Zdroj: | Allergy and Asthma Proceedings. 39:e30-e37 |
| ISSN: | 1088-5412 |
| DOI: | 10.2500/aap.2018.39.4135 |
| Popis: | BACKGROUND Local allergic rhinitis (LAR) is rhinitis with a localized nasal allergic response in the absence of systemic allergy. This study aimed to evaluate the pathogenesis specific to LAR compared with allergic rhinitis (AR) and nonallergic rhinitis (NAR) by using cytokines from polypous tissues. METHODS We recruited 43 patients with AR (n = 15; mean age, 17.4 years), LAR (n = 12; mean age, 15.9 years), and NAR (n = 16; mean age, 15.6 years) who underwent polypectomy. Atopic status was defined as presenting a sufficiently high total immunoglobulin E (IgE) serum concentration and skin-prick test or serum allergen test. Immunoassays were performed by using polyp tissue homogenates to quantify the levels of regulated on activation of normal T cell expressed and secreted (RANTES), tumor necrosis factor (TNF) alpha, interleukin (IL) 5, and sera to assess total IgE and eosinophil cationic protein. RESULTS RANTES levels were higher in patients with LAR than in patients with AR and NAR. There was a significant correlation in the concentration of RANTES between polyp tissue homogenates and serum (R2 = 0.51, p < 0.05). The levels of IL-5, TNF alpha, and interferon gamma also demonstrated positive correlations between polyp tissue homogenates and serum; however, they were not significantly different. CONCLUSION Results of our study indicated that RANTES may play an important role and contribute to allergic reaction in LAR, and RANTES may be related to the pathogenesis of LAR. |
| Databáze: | OpenAIRE |
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