Clinical Implications of Carcinoma In Situ in Sinonasal Inverted Papilloma
| Autor: | David W. Kennedy, Peter Papagiannopoulos, Noam A. Cohen, Edward C. Kuan, Nithin D. Adappa, James N. Palmer, Esther Baranov, Justina L. Lambert, Neil N. Patel, Michael A. Kohanski, Charles C. L. Tong, Vasiliki Triantafillou, Ivy W. Maina, Carol H. Yan, Alan D. Workman, Michael Feldman |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Inverted papilloma Malignancy Malignant transformation Sinonasal inverted papilloma medicine Humans Aged Retrospective Studies Papilloma Inverted business.industry Carcinoma in situ Endoscopy Middle Aged medicine.disease Combined Modality Therapy Survival Rate Treatment Outcome Otorhinolaryngology Dysplasia Surgery Female business Carcinoma in Situ Paranasal Sinus Neoplasms |
| Zdroj: | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 161(6) |
| ISSN: | 1097-6817 |
| Popis: | Sinonasal inverted papilloma (IP) is a typically benign sinonasal tumor with a tendency to recur and the potential for malignant transformation. Varying degrees of dysplasia may be present, of which carcinoma in situ (CIS) is most advanced. We hereby describe the biological and clinical behavior of IP with CIS (IPwCIS).Retrospective cohort.Tertiary academic referral center.Patients who underwent surgical resection for IP between 2002 and 2017. Pertinent clinical data were obtained, and all IPwCIS cases were histologically confirmed.In total, 37 of 215 cases (17.2%) were identified with IPwCIS. Mean age was 57 years and 86.5% of patients were male. Median follow-up was 82 months, and the recurrence rate was 27%. The maxillary sinus was the most common primary site (37.8%) and 14 tumors (37.8%) demonstrated multifocal attachment, which was associated with recurrence (odds ratio [OR], 9.7; 95% confidence interval [CI], 1.4-112.8;IPwCIS represents the most severe degree of dysplasia prior to malignant transformation and is associated with higher recurrence rate and multifocal involvement but low rate of conversion to invasive carcinoma. The need for adjuvant therapy remains controversial, and further research into the etiology of the disease is warranted. |
| Databáze: | OpenAIRE |
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