Distinct Vasodilation, without Reflex Neurohormonal Activation, Induced by Barnidipine in Hypertensive Patients
| Autor: | N. De Luca, Gianni Luigi Iovino, Bruno Trimarco, Raffaele Izzo, L. Argenziano, Carmine Morisco, L Parrella |
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| Přispěvatelé: | L., Argenziano, Izzo, Raffaele, G., Iovino, DE LUCA, Nicola, L., Parrella, Morisco, Carmine, Trimarco, Bruno |
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Sympathetic Nervous System Barnidipine Supine position Nifedipine Hemodynamics Blood Pressure Vasodilation Essential hypertension Placebo Double-Blind Method Nitrendipine Internal medicine Reflex Internal Medicine medicine Humans Antihypertensive Agents business.industry General Medicine Middle Aged Calcium Channel Blockers medicine.disease Endocrinology Blood pressure Hypertension Cardiology Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1651-1999 0803-7051 |
| DOI: | 10.1080/080370598438546 |
| Popis: | Barnidipine is a new 1,4-dihydropyridine calcium antagonist with a strong and long-lasting vasodilatory effect. In order to assess the haemodynamic profile of the antihypertensive effect of barnidipine, a randomized, double-blind study of barnidipine vs nitrendipine was performed in 24 patients with mild to moderate essential hypertension. Following an initial 4-week placebo period, patients whose sitting diastolic blood pressure (SiDBP) was between 95 and 114 mm Hg, and whose sitting systolic blood pressure was between 150 and 219 mm Hg, were randomized (2:1 ratio) to receive either barnidipine (10 mg) or nitrendipine (10 mg) once daily, for a 6-week double-blind period. Subsequently, patients with an SiDBP of less than 90 mm Hg continued for a second 6-week period with the same monotherapy, while patients with an SiDBP of 90 mm Hg or above received double the dose of antihypertensive treatment for the next 6 weeks. Two-dimensional M- and B-mode echocardiography with Doppler flowmetry was performed at the end of both the placebo and active treatment phases. Barnidipine and nitrendipine reduced blood pressure by the same degree (barnidipine: from 165 +/- 2/100 +/- 1 to 145 +/- 2/89 +/- 1 mm Hg, p < 0.01; nitrendipine: from 163 +/- 3/100 +/- 2 to 143 +/- 7/90 +/- 3 mm Hg, p < 0.01) as a result of peripheral vasodilation. This was not accompanied by reflex neurohormonal activation. Moreover, only in the group receiving barnidipine was a significant decrease in plasma noradrenaline observed, both when the patients were in the supine position (from 298 +/- 27 to 214 +/- 21 pg/ml, p < 0.05) and when they were upright (from 472 +/- 37 to 348 +/- 38 pg/ml, p < 0.05). |
| Databáze: | OpenAIRE |
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