Axonal synapse sorting in medial entorhinal cortex
| Autor: | Michael Brecht, Jakob Straehle, Anjali Gour, Helene Schmidt, Kevin M Boergens, Moritz Helmstaedter |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Models Neurological Neurophysiology Biology Inhibitory postsynaptic potential Synapse 03 medical and health sciences Imaging Three-Dimensional 0302 clinical medicine Excitatory synapse Interneurons Postsynaptic potential Neural Pathways Connectome medicine Animals Entorhinal Cortex Multidisciplinary Sorting Excitatory Postsynaptic Potentials Neural Inhibition Dendrites Anatomy Axons Rats Microscopy Electron 030104 developmental biology medicine.anatomical_structure nervous system Cerebral cortex Synapses Excitatory postsynaptic potential Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nature, 549, pp. 469-475 Nature, 549, 469-475 Nature |
| ISSN: | 0028-0836 |
| Popis: | Research on neuronal connectivity in the cerebral cortex has focused on the existence and strength of synapses between neurons, and their location on the cell bodies and dendrites of postsynaptic neurons. The synaptic architecture of individual presynaptic axonal trees, however, remains largely unknown. Here we used dense reconstructions from three-dimensional electron microscopy in rats to study the synaptic organization of local presynaptic axons in layer 2 of the medial entorhinal cortex, the site of grid-like spatial representations. We observe path-length-dependent axonal synapse sorting, such that axons of excitatory neurons sequentially target inhibitory neurons followed by excitatory neurons. Connectivity analysis revealed a cellular feedforward inhibition circuit involving wide, myelinated inhibitory axons and dendritic synapse clustering. Simulations show that this high-precision circuit can control the propagation of synchronized activity in the medial entorhinal cortex, which is known for temporally precise discharges. |
| Databáze: | OpenAIRE |
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