The genetics of blind—a lethal factor in mice

Autor:	Ernst Caspari, Luz S. Teicher
Rok vydání:	1978
Předmět:	Male Genetics X Chromosome Genetic Linkage Mice Inbred Strains Biology Blindness Penetrance Molecular biology Lethal factor Mice Chromosome 15 Phenotype Animals Lethal allele Female Genes Lethal Molecular Biology Gene Crosses Genetic Genetics (clinical) Biotechnology
Zdroj:	Journal of Heredity. 69:86-90
ISSN:	1465-7333 0022-1503
DOI:	10.1093/oxfordjournals.jhered.a108910
Popis:	The linkage relationships of the lethal gene blind (Bld) in the mouse were investigated. The gene is located on chromosome 15, between uw and bt. The distance uw--Bld is 28.2 +/- 5.1 cM: Bld--bt is 14.9 +/- 2.7 cM: and Bld--Ca is 24.6 +/- 2.6 cM. Incomplete penetrance and/or reduced viability of Bld/+ animals was found when blind animals were crossed to several strains, but the cross female DBA/2J X male blind yielded complete penetrance and specificity. Evidence is presented for the presence of X-linked modifiers affecting the penetrance and possible increased viability of Bld in strain DBA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93fb6ad8a0241c002b4cb8e674042f9e https://doi.org/10.1093/oxfordjournals.jhered.a108910 Zobrazit plný text záznamu