Regioselective Difluoromethane sulfonylation and Triflylation of Resorufin Derivatives

Autor:	Qingwei Tan, Huiling Tang, Yuyao Li, Yefeng Chen, Hexin Xie, Jialing Jiang, Yan Peng, Shuxuan Zhao
Rok vydání:	2021
Předmět:	Sulfonyl chemistry.chemical_classification Organic Chemistry Regioselectivity Chromophore Biochemistry Combinatorial chemistry Fluorescence symbols.namesake chemistry.chemical_compound chemistry Stokes shift symbols Physical and Theoretical Chemistry Solubility Difluoromethane
Zdroj:	Organic Letters. 23:8477-8481
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.1c03192
Popis:	Reported herein is a regioselective difluoromethane sulfonylation or triflylation of resorufin derivatives, which allows easy access to 2-difluoromethane sulfonylated or triflylated resorufin derivatives in good yields. The installation of a difluoromethane sulfonyl group significantly increases the solubility of the chromophore and expands its Stokes shift. A difluoromethane sulfonylated resorufin-based fluorogenic probe proved to be able to image enzyme activity in live cells with a stronger fluorescence signal compared with its resorufin counterpart.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f776c98348a2dfa5cdcb8ee2a1d205 https://doi.org/10.1021/acs.orglett.1c03192 Zobrazit plný text záznamu