Toxicity and bioaccumulation of Cadmium, Copper and Zinc in a direct comparison at equitoxic concentrations in common carp (Cyprinus carpio) juveniles
| Autor: | Božidar Rašković, Gudrun De Boeck, Vyshal Delahaut, Lieven Bervoets, Marta Satorres Salvado, Ronny Blust |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Gills
Respiratory System 010501 environmental sciences medicine.disease_cause Toxicology Pathology and Laboratory Medicine Median lethal dose 01 natural sciences Common carp Medicine and Health Sciences Animal Anatomy 0303 health sciences Cadmium Multidisciplinary biology Copper toxicity Eukaryota Bioaccumulation Zinc Chemistry Osteichthyes Physical Sciences Vertebrates Toxicity Medicine Anatomy Engineering sciences. Technology Research Article Chemical Elements Carps Fish Biology Science Sodium chemistry.chemical_element Lethal Dose 50 03 medical and health sciences Animal science medicine Fish Physiology Animals Animal Physiology 14. Life underwater Carp 030304 developmental biology 0105 earth and related environmental sciences Organisms Biology and Life Sciences medicine.disease biology.organism_classification Copper Vertebrate Physiology Fish Aquatic Respiratory Anatomy chemistry Zinc toxicity Zoology Water Pollutants Chemical |
| Zdroj: | PLoS ONE Plos One PLoS ONE, Vol 15, Iss 4, p e0220485 (2020) |
| ISSN: | 1932-6203 |
| Popis: | The individual toxicity and bioaccumulation of cadmium, copper and zinc for common carp juveniles was evaluated in a direct comparison in two experimental setups. First, fish were exposed for 10 days to different metal concentrations in order to link metal bioaccumulation to LC50 values (concentration lethal to 50% of the animals) and incipient lethal levels (ILL, concentration where 50% survives indefinitely). Accumulated metals showed a positive dose dependent uptake for cadmium and copper, but not for zinc. Toxicity was in the order cadmium>copper>zinc with 96h LC50 values for cadmium at 0.20 +/- 0.16 mu M, for copper at 0.77 +/- 0.03 mu M, and for zinc at 29.89 +/- 9.03 mu M respectively. For copper, the 96h exposure was sufficient to calculate the incipient lethal level and therefore 96h LC50 and ILL levels were the same, while for cadmium and zinc 5 to 6 days were needed to reach ILL resulting in slightly lower values at 0.16 mu M and 28.33 mu M respectively. Subsequently, a subacute exposure experiment was conducted, where carp juveniles were exposed to 2 equitoxic concentrations (10% and 50% of LC50 96 h) of the three metals for 1, 3 and 7 days. Again a significant dose-dependent increase in gill cadmium and copper, but not in zinc, was observed during the 7-day exposure. Copper clearly affected sodium levels in gill tissue, while zinc and cadmium did not significantly alter any of the gill electrolytes. The overall histopathological effects (e.g. hyperemia and hypertrophy) of the metal exposures were mild for most of the alterations. Our study showed that copper an cadmium (but not zinc) showed dose dependent metal accumulation, however this bioaccumulation was only correlated with mortality for cadmium. Metal specific alterations were reduced gill sodium levels in copper exposed fish and oedema of the primary epithelium which typically occurred in both levels of zinc exposure. |
| Databáze: | OpenAIRE |
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