Pharmacotherapy of binge-eating disorder: a review
| Autor: | Francesco Casamassima, Jim Benbow, Silvia di Volo, Andrea Fagiolini, Arianna Goracci, Simone Bolognesi |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
MEDLINE substance abuse treatment agents law.invention Pharmacotherapy Randomized controlled trial Binge-eating disorder law binge eating disorder Humans Medicine Pharmacology (medical) Sympathomimetics Psychiatry antiobesity agents Binge eating business.industry Retrospective cohort study medicine.disease Antidepressive Agents Psychiatry and Mental health Lisdexamfetamine anticonvulsants antidepressants Anti-Obesity Agents medicine.symptom business Binge-Eating Disorder Psychopathology medicine.drug |
| Popis: | Objectives The purpose of this article is to provide a comprehensive review of pharmacotherapy for binge eating disorder, including new therapeutic approaches such as centrally acting sympathomimetics, nootropics, lisdexamfetamine, and substance abuse treatment agents such as acamprosate, sodium oxybate, baclofen, and naltrexone. Methods The study was conducted by searching the MEDLINE database using the keywords "binge eating disorder," "obesity," and "pharmacological therapy."All available studies on each drug dating from 1988 to the present were considered, focusing mainly on randomized controlled trials (RCTs). Other types of studies were considered when no RCTs were found. We drafted separate tables for open-label studies (), RCT (), and retrospective studies (). Each study is detailed by the number of subjects, additional design considerations, doses, results, additional main comparators, and study limitations. Results The data emerging from this study seem to show that, at least in the short term, some specific medications within the classes of antidepressants, anticonvulsants, and antiobesity agents may prove promising in achieving the main objectives in the treatment of binge eating disorder: reducing the frequency of binge eating, reducing weight, and improving the associated psychopathology. The major limitation in interpreting these results is the short duration of the studies and the lack of adequately sized trials, or trials including patients with medical comorbidities.Good results are being obtained with new combinations of drugs and with substance abuse treatment agents. Although the precise nature of the relationship between substance use disorders and binge eating disorder remains to be clarified, the evidence suggests that treatments recognized as effective for substance use disorders may be useful as novel treatments for binge eating disorder. This field of research remains open to future studies with more precise methodological approaches and more detailed parameter assessment; a multidisciplinary approach is also essential to better understand such a complex disease. |
| Databáze: | OpenAIRE |
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