Effects of preemptive interferon-α monotherapy in acute leukemia patients with relapse tendency after allogeneic hematopoietic stem cell transplantation: a case-control study
| Autor: | Sheng-Li Xue, Zheng-Min Jin, Xiao-Ji Lin, Miao Miao, Huiying Qiu, Xinliang Mao, Aining Sun, Ai-Jing Wang, Xiao Ma, Haiping Dai, Feng Chen, Depei Wu, Xia-Ming Zhu, Xiaowen Tang |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Graft vs Host Disease Disease Hematopoietic stem cell transplantation Gastroenterology Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Recurrence Internal medicine Interferon α Humans Medicine Cumulative incidence Child Response rate (survey) Acute leukemia Leukemia Hematology business.industry Hematopoietic Stem Cell Transplantation Case-control study Interferon-alpha General Medicine Middle Aged Allografts Survival Rate 030220 oncology & carcinogenesis Acute Disease Chronic Disease Female business 030215 immunology |
| Zdroj: | Annals of Hematology. 97:2195-2204 |
| ISSN: | 1432-0584 0939-5555 |
| DOI: | 10.1007/s00277-018-3429-z |
| Popis: | Interferon-α (IFN-α) inhibits tumor growth and mimics graft-versus-leukemia after allogeneic hematopoietic stem cell transplantation (allo-HSCT). In the current case-control study, we compared treatment responses in acute leukemia patients with relapse tendency post-allo-HSCT receiving preemptive IFN-α after withdrawal of immunosuppressants (n = 31) vs. receiving no IFN-α (n = 67). In the IFN-α group, 25 patients responded to the treatment without progressing to hematological relapse. In the non-IFN-α group, only 22 patients responded to the treatment. The response rate differed significantly (80.6 vs. 32.8%, P |
| Databáze: | OpenAIRE |
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