Antigenotoxic, Anti-photogenotoxic, and Antioxidant Properties of Polyscias filicifolia Shoots Cultivated In Vitro
| Autor: | Agata Soluch, Anita Śliwińska, Anna Zgadzaj, Agnieszka Pietrosiuk, Ramona Figat, Katarzyna Sykłowska-Baranek, Magdalena Sobczak, Anna Stochmal |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Salmonella typhimurium chlorogenic acid Saponin Pharmaceutical Science medicine.disease_cause 01 natural sciences antigenotoxic agents Analytical Chemistry lcsh:QD241-441 Ferulic acid 03 medical and health sciences chemistry.chemical_compound lcsh:Organic chemistry Chlorogenic acid Drug Discovery Caffeic acid medicine Physical and Theoretical Chemistry Medicinal plants 030304 developmental biology chemistry.chemical_classification 0303 health sciences Traditional medicine biology Organic Chemistry biology.organism_classification chemistry Phytochemical Chemistry (miscellaneous) Molecular Medicine Araliaceae caffeic acid Genotoxicity 010606 plant biology & botany ferulic acid |
| Zdroj: | Molecules Volume 25 Issue 5 Molecules, Vol 25, Iss 5, p 1090 (2020) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules25051090 |
| Popis: | Traditional medicinal plants are an important source of active compounds with potential antimutagenic activity. Polyscias filicifolia Bailey (Araliaceae) is a South Asian traditional herb used as an adaptogenic and cardiac drug. Extracts of P. filicifolia contain a wide range of biologically active compounds like phenolic acids and triterpenoid saponins. In the present study. antigenotoxic potential of three naturally occurring phenolic acids and extracts of P. filicifolia growing in vitro with the addition of elicitors was evaluated against direct (4-nitroquinoline-N-oxide (4NQO) and mitomycin C (MMC)) and indirect mutagens (2-aminoanthracene (2AA)). The evaluation was made using a bacterial umu-test. Moreover, the ability to prevent photogenotoxicity induced by chlorpromazine (CPZ) under UVA irradiation was measured. The phytochemical profiling of examined extracts revealed the presence of numerous compounds with the prevelance of chlorogenic, caffeic, and ferulic acid derivatives however, saponin fractions were also determined. The antioxidant potential of extracts strictly correlated with their composition. The tested extracts exhibited high antigenotoxic activity if the assay was performed with 2AA and metabolic activation. Moreover, the extracts slightly decreased the MMC-induced genotoxicity. However, an increase of the genotoxic effect was observed in the assay performed with 4NQO. In addition, photo-antigenotoxic activity was observed. In our study, phenolic acids exhibited lower activity than the extracts. |
| Databáze: | OpenAIRE |
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