Synthesis of a ditopic cyclophane based on the cyclobutane ring by chalcone photocycloaddition
| Autor: | Francesca R Cibin, Giancarlo Doddi, Paolo Mencarelli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Chalcone
Cyclobutanes photochemistry Stereochemistry Organic Chemistry carbocycles Ring (chemistry) Biochemistry enones Cycloaddition Cyclobutane chemistry.chemical_compound chemistry Intramolecular force Drug Discovery cyclophanes Two-dimensional nuclear magnetic resonance spectroscopy cycloaddition Cyclophane |
| Popis: | The intramolecular photocycloaddition of chalcones to give cyclobutanes has proven to be a fast and simple method to shrink a cyclophane ring to a tricyclic system, in order to prepare potential ditopic receptors. In particular, the chalcone 1, having dioxyethylene chains as spacers, is converted in high yield to the cyclobutane 2. NOESY spectroscopy indicates that the formation of 2 occurs by a head-to-head syn ring closure. |
| Databáze: | OpenAIRE |
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