A prospective, randomized, double-blinded comparison of ropivacaine 0.5%, 0.75%, and 1% ropivacaine for peribulbar block
| Autor: | Francesco Fasce, Angela Sciascia, Monica Scarioni, Elisa Cerchierini, Luigi Gioia, Andrea Casati, Guido Fanelli, Alessandra Garassino, Umberto Nuti, Roberta Mennella, Gianluigi Bolognesi, Giorgio Torri |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.drug_class medicine.medical_treatment Hyaluronoglucosaminidase Cataract Extraction Double-Blind Method Heart rate medicine Humans Ropivacaine Prospective Studies Anesthetics Local Prospective cohort study Aged Dose-Response Relationship Drug business.industry Local anesthetic Nerve Block Cataract surgery Amides Surgery Treatment Outcome Anesthesiology and Pain Medicine Blood pressure Anesthesia Anesthesia Recovery Period Nerve block Female business medicine.drug |
| Zdroj: | Journal of Clinical Anesthesia. 16:184-188 |
| ISSN: | 0952-8180 |
| DOI: | 10.1016/j.jclinane.2003.07.004 |
| Popis: | Study objective To evaluate the efficacy of three different concentrations of ropivacaine (0.5%, 0.75%, and 1%) together with a single concentration of hyaluronidase administered for peribulbar block. Design Prospective, randomized, double-blind study. Setting Anesthesia department of a university teaching hospital. Patients 68 ASA physical status I, II, and III patients undergoing elective cataract surgery. Interventions Patients were randomly allocated to receive peribulbar block with 6.5 mL of either 0.5% (Group Ropi-5; n=22), 0.75% (Group Ropi-7.5; n=22), or 1% ropivacaine (Group Ropi-10; n=24). In all patients, 0.5 mL of hyaluronidase was added to the local anesthetic solution. Measurements and main results A larger proportion of patients in Groups Ropi-7.5 (82%) and Ropi-10 (83%) showed complete motor block 15 minutes after injection compared with Group Ropi-5 (55%; p = 0.05, and p = 0.03, respectively). Hypotension (reduction of systolic blood pressure by 30% or more from baseline) was observed in two Group Ropi-5 patients (9%), and two Group Ropi-7.5 patients (9%; p = 0.31), whereas bradycardia (reduction in heart rate ≤ 50 bpm) was observed in one Group Ropi-5 patient (4%), and three Group Ropi-10 patients (12%; p = 0.18). Seven hours after surgery, a smaller proportion of Group Ropi-10 patients (64%) showed complete recovery of sensory function as compared with both Group Ropi-5 (94%) and Group Ropi-7.5 (90%; p = 0.03 and p = 0.03, respectively). Complete recovery of motor function 1 hour after surgery was more frequent in Group Ropi-5 (37%) than in Group Ropi-7.5 (5%) or Group Ropi-10 (9%; p = 0.05 and p = 0.05, respectively); however, no other differences in recovery of motor function were observed at any other observation times, with complete recovery in all patients 7 hours after surgery. Conclusions While confirming that ropivacaine is a good option for peribulbar anesthesia, this study demonstrated that the use of 0.75% or 1% concentrations are preferred in that they produce quick and deep sensory and motor block of the operated eye. If recovery of normal motor function is important after surgery, the 0.75% concentration probably represents the best compromise. |
| Databáze: | OpenAIRE |
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