Modification of Epigenetic Patterns in Low Birth Weight Children: Importance of Hypomethylation of the ACE Gene Promoter
| Autor: | Maria do Carmo Franco, Miriam Galvonas Jasiulionis, Jessica Cassilla dos Santos, Mario Hiroyuki Hirata, Marina Rangel, Ronaldo C. Araujo, Paula Helena Lima Ortiz, Daniela Filippini Ierardi |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Epigenomics
Male Candidate gene Blood Pressure Biochemistry Pediatrics Vascular Medicine Body Mass Index Epigenesis Genetic Child Development Nucleic Acids Genotype Blood plasma Medicine and Health Sciences Leukocytes Public and Occupational Health Child Promoter Regions Genetic Multidisciplinary Child Health Methylation CpG site Research Design Hypertension DNA methylation Medicine Epigenetics Female Research Article medicine.medical_specialty Child Growth Clinical Research Design Science Cardiology Peptidyl-Dipeptidase A Biology Research and Analysis Methods Internal medicine Genetics medicine Humans Growth Restriction Biology and Life Sciences DNA DNA Methylation Infant Low Birth Weight Cross-Sectional Studies Endocrinology Immunology CpG Islands |
| Zdroj: | PLoS ONE, Vol 9, Iss 8, p e106138 (2014) PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0106138 |
| Popis: | There is a growing body of evidence that epigenetic alterations are involved in the pathological mechanisms of many chronic disorders linked to fetal programming. Angiotensin-converting enzyme (ACE) appears as one candidate gene that brings new insights into the epigenetic control and later development of diseases. In this view, we have postulated that epigenetic modifications in the ACE gene might show different interactions between birth weight (BW), blood pressure levels, plasma ACE activity and ACE I/D polymorphism. To explore this hypothesis, we performed a cross-sectional study to evaluate the DNA methylation of 3 CpG sites using pyrosequencing within the ACE gene promoter of peripheral blood leukocytes from 45 LBW children compared with 70 NBW children. Our results have revealed that LBW children have lower methylation levels (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|