Assessment of the Effect of Structural Modification of Ibuprofen on the Penetration of Ibuprofen from Pentravan® (Semisolid) Formulation Using Human Skin and a Transdermal Diffusion Test Model
| Autor: | Ewa Janus, Joanna Klebeko, Marta Markowska, Piotr Bargiel, Wiktoria Duchnik, Jan Petriczko, Anna Nowak, Norbert Czapla, Łukasz Kucharski, Adam Klimowicz, Urszula Adamiak-Giera, Paula Ossowicz-Rupniewska, Piotr Prowans |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Technology
Pentravan® Franz cell diffusion Strat-M® Human skin medicine General Materials Science Alkyl Transdermal chemistry.chemical_classification Microscopy QC120-168.85 Chromatography increasing drug permeability organic chemicals QH201-278.5 Penetration (firestop) structural modification of ibuprofen transdermal delivery system Permeation Ibuprofen Engineering (General). Civil engineering (General) TK1-9971 Membrane chemistry Descriptive and experimental mechanics Electrical engineering. Electronics. Nuclear engineering TA1-2040 human skin Isopropyl medicine.drug |
| Zdroj: | Materials Volume 14 Issue 22 Materials, Vol 14, Iss 6808, p 6808 (2021) |
| ISSN: | 1996-1944 |
| DOI: | 10.3390/ma14226808 |
| Popis: | The effect of transdermal vehicle (Pentravan®) on skin permeability was examined for unmodified ibuprofen (IBU) and ion pairs of ibuprofen with new L-valine alkyl esters [ValOR][IBU]. The percutaneous permeation across the human skin and transdermal diffusion test model (Strat-M® membranes) of ibuprofen and its structural modification were measured and compared using Franz diffusion cells. For comparison, the penetration of ibuprofen from a commercial product was also investigated. The cumulative amount of drug permeated through human skin at the end of the 24 h study was highest for ibuprofen derivatives containing propyl (C3), isopropyl (C3), ethyl (C2), and butyl (C4) esters. For Strat-M®, the best results were obtained with the alkyl chain length of the ester from C2 to C5. The permeation profiles and parameters were appointed, such as steady-state flux, lag time, and permeability coefficient. It has been shown that L-valine alkyl ester ibuprofenates, with the propyl, butyl, and amyl chain, exhibit a higher permeation rate than ibuprofen. The diffusion parameters of analyzed drugs through human skin and Strat-M® were similar and with good correlation. The resulting Pentravan-based creams with ibuprofen in the form of an ionic pair represent a potential alternative to other forms of the drug-containing analgesics administered transdermally. Furthermore, the Strat-M® membranes can be used to assess the permeation of transdermal preparations containing anti-inflammatory drugs. |
| Databáze: | OpenAIRE |
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