Malformations among infants of mothers with insulin-dependent diabetes: Is there a recognizable pattern of abnormalities?
| Autor: | Hanah Nasri, Lewis B. Holmes, Anne-Therese Hunt, Marie-Noel Westgate, Kara Houde Ng |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Embryology Pediatrics medicine.medical_specialty Health Toxicology and Mutagenesis Pregnancy in Diabetics 030105 genetics & heredity Kidney Toxicology Congenital Abnormalities Diabetes Complications 03 medical and health sciences Dysgenesis Pregnancy Double outlet right ventricle Diabetes mellitus Anencephaly medicine Humans business.industry Medical record medicine.disease Double Outlet Right Ventricle Gestational diabetes Bilateral Renal Agenesis Diabetes Mellitus Type 1 Great arteries Pediatrics Perinatology and Child Health Female Kidney Diseases business Developmental Biology |
| Zdroj: | Birth Defects Research. 110:108-113 |
| ISSN: | 2472-1727 |
| DOI: | 10.1002/bdr2.1155 |
| Popis: | Background Infants of diabetic mothers have been shown in several studies to have an increased frequency of malformations. In previous studies, an increased frequency of several specific malformations has been noted, including anencephaly, bilateral renal agenesis, and double outlet right ventricle. Surveillance, used to identify all malformed infants in a consecutive sample of births, can identify a distinctive pattern of malformations among the affected infants. Methods The infants of insulin-dependent, pregestational diabetic mothers were identified in the daily review of the medical records of each newborn infant with a malformation and her/his mother's medical record. Infants of mothers with gestational diabetes were excluded. The frequency of each malformation was compared to that among the malformed infants of nondiabetic mothers. Results One hundred and eighty-three malformed infants of diabetic mothers were identified among the 289,365 births. The most notable malformations were: neural tube defects (anencephaly, 9%), heart defects (transposition of great arteries, 4%), bilateral renal agenesis or dysgenesis (6%), and vertebral anomalies (hemivertebrae, 4%). Conclusions There was a recognizable pattern of malformations and characteristics of infants of diabetic mothers, although there was variation in the pattern among affected infants. Some of the malformations in the diabetic embryopathy can be identified in prenatal screening by ultrasound. More important, their occurrence can be reduced significantly by the mother achieving much better control of her diabetes mellitus prior to conception. |
| Databáze: | OpenAIRE |
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