Characterization of a degenerative cardiomyopathy associated with domoic acid toxicity in California sea lions (Zalophus californianus)
| Autor: | Tanja S. Zabka, Santokh Gill, Tracey Goldstein, Rudi Mueller, Frances M. D. Gulland, C. Cross, C. Kreuder-Johnson |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Pathology medicine.medical_specialty Zalophus californianus Neurotoxins Cardiomyopathy Biology Pathogenesis Lesion chemistry.chemical_compound Blood serum medicine Animals Kainic Acid General Veterinary Chronic Active Caspase 3 Dissection Myocardium Domoic acid Sequela medicine.disease biology.organism_classification Immunohistochemistry Sea Lions chemistry Female Marine Toxins medicine.symptom Cardiomyopathies |
| Zdroj: | Veterinary pathology. 46(1) |
| ISSN: | 0300-9858 |
| Popis: | Domoic acid, produced by marine algae, can cause acute and chronic neurologic sequela in California sea lions (Zalophus californianus) from acute toxicity or sublethal exposure. Eight sea lions, representing acute and chronic cases, both sexes, and all age classes, were selected to demonstrate a concurrent degenerative cardiomyopathy. Critical aspects of characterizing the cardiomyopathy by lesion distribution and morphology were the development of a heart dissection and tissue-trimming protocol and the delineation of the cardiac conducting system by histomorphology and immunohistochemistry for neuron-specific protein gene product 9.5. Histopathologic features and progression of the cardiomyopathy are described, varying from acute to chronic active and mild to severe. The cardiomyopathy is distinguished from other heart lesions in pinnipeds. Based on histopathologic features, immunopositive staining for cleaved caspase-3, and comparison with known, similar-appearing cardiomyopathies, the proposed pathogenesis for the degenerative cardiomyopathy is the primary or at least initial direct interaction of domoic acid with receptors that are suspected to exist in the heart. L-Carnitine, measured in the heart and skeletal muscle, and troponin-I, measured in serum collected at the time of death from additional animals (n = 58), were not predictive of the domoic acid-associated cardiomyopathy. This degenerative cardiomyopathy in California sea lions represents another syndrome beyond central neurologic disease associated with exposure to domoic acid and may contribute to morbidity and mortality. |
| Databáze: | OpenAIRE |
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