Prothrombotic State in Asthma Is Related to Increased Levels of Inflammatory Cytokines, IL-6 and TNFα, in Peripheral Blood

Autor: Lech Zareba, Anetta Undas, Teresa Iwaniec, Lucyna Mastalerz, Romy Kremers, Michal Zabczyk, Agnieszka Cybulska, Grazyna Pulka, Stanisława Bazan-Socha, Coenraad Hemker
Přispěvatelé: RS: CARIM - R1.01 - Blood proteins & engineering, Promovendi CD, Biochemie
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
SYSTEMIC INFLAMMATION
medicine.medical_treatment
ADULT-ONSET ASTHMA
030204 cardiovascular system & hematology
Systemic inflammation
0302 clinical medicine
TNFα
Immunology and Allergy
Thrombophilia
TUMOR-NECROSIS-FACTOR
$TNF\alpha$
RISK
periostin
biology
medicine.diagnostic_test
Fibrinolysis
Thrombin
Middle Aged
thrombin generation
Cytokines
fibrinolysis
Original Article
Female
Prothrombin
medicine.symptom
Inflammation Mediators
Spirometry
Adult
Thrombin generation
Immunology
COAGULATION
Inflammation
Periostin
Proinflammatory cytokine
03 medical and health sciences
medicine
Humans
CORONARY-HEART-DISEASE
PLASMINOGEN-ACTIVATOR
Interleukin 6
Asthma
IL-6
business.industry
Interleukin-6
Tumor Necrosis Factor-alpha
asthma
medicine.disease
030228 respiratory system
TISSUE FACTOR
Case-Control Studies
biology.protein
business
TNF alpha
Cell Adhesion Molecules
Zdroj: Inflammation
Inflammation, 40(4), 1225-1235. Springer
ISSN: 1573-2576
0360-3997
Popis: Recently, we have reported that asthma is associated with enhanced plasma thrombin formation and impaired fibrinolysis. The mechanisms underlying the prothrombotic state in this disease are unknown. Our aim was to investigate whether prothrombotic alterations in asthmatics are associated with inflammation.We studied 164 adult, white, stable asthmatics and 72 controls matched for age, sex, body mass index (BMI), and smoking. Plasma tumor necrosis factor $\alpha$ ($TNF\alpha$), interleukin (IL)-6, and serum periostin were evaluated using ELISAs, and their associations with thrombin generation, fibrinolytic capacity, expressed as clot lysis time (CLT), and platelet markers were later analyzed. Asthma was characterized by 62% higher plasma IL-6 and 35% higher $TNF\alpha$ (both, p < 0.0001). Inflammatory cytokines were higher in sporadic and persistent asthmatics compared to controls, also after adjustment for potential confounders. IL-6 was inversely related to the forced expiratory volume in 1 s/vital capacity (FEV1/VC) spirometry index after correction for age, sex, and BMI. IL-6 and $TNF\alpha$ were associated with C-reactive protein in asthmatics ($\beta$ = 0.6 [95% CI, 0.54-0.67] and $\beta$ = 0.33 [95% CI, 0.25-0.41], respectively) and controls ($\beta$ = 0.43 [95% CI, 0.29-0.57] and $\beta$ = 0.33 [95% CI, 0.18-0.48], respectively). In asthma, IL-6 and $TNF\alpha$ positively correlated with the endogenous thrombin potential ($\beta$ = 0.35 [95% CI, 0.28-0.42] and \beta = 0.15 [95% CI, 0.07-0.23], respectively) but not with CLT or platelet markers. However, $TNF\alpha$ predicted CLT in a multiple linear regression model. Periostin was not associated with any hemostatic parameters. Enhanced thrombin generation is driven in asthma by a systemic inflammatory state mediated by IL-6 and to a lesser extent $TNF\alpha$, however, not periostin. $TNF\alpha$ might contribute to impaired fibrinolysis.
Databáze: OpenAIRE
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