Roles of regulatory T Cells in pathogenesis of endometriosis
| Autor: | Xiao-Qiu Wang, Xin-Xin Hou, Da-Jin Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
lcsh:RC648-665 business.industry Endometrial Stromal Cells Endometriosis Fibrinogen-Like Protein 2 Regulatory T Cells medicine.medical_treatment Disease progression Obstetrics and Gynecology Immune Cell Function Immunosuppression chemical and pharmacologic phenomena Disease medicine.disease lcsh:Diseases of the endocrine glands. Clinical endocrinology FGL2 Pathogenesis Immune system Reproductive Medicine Immunology medicine business lcsh:RC581-607 |
| Zdroj: | Reproductive and Developmental Medicine, Vol 3, Iss 2, Pp 117-123 (2019) |
| ISSN: | 2589-8728 2096-2924 |
| Popis: | Numerous studies have shown aberrant immune cell function in endometriosis, including T cells, B cells, natural killer cells, and macrophages (Mφ). These alterations are thought to be induced by various mechanisms that promote the disease. Regulatory T cells (Tregs) may account for a decreased ability of newly recruited leukocytes to initiate effective immune responses against viable endometrial fragments, permitting their survival. Tregs differentiate during the development of endometriosis, which confer immunosuppression or play other roles in disease progression. In this review, we provide an overview of the regulation and roles of Tregs in endometriosis. These data provide further scientific evidence for the altered immune response in endometriosis, which could be a potential target in the treatment of endometriosis. This review could create new diagnostic strategies and effective immune-targeted therapies for this highly prevalent disease. Recent progress in the field indicates that these goals may be achieved in the future. |
| Databáze: | OpenAIRE |
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