Candidate gene association studies of the α4 (CHRNA4) and β2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease
| Autor: | Corinne Lendon, Sarah Walter, D. Turic, John Grimley Evans, Antonia L. Pritchard, Amanda J. Edmondson, Lynnette J. Cook, Pamela Moore, Nigel J. Cairns, Alison Taylor, Helen Lemmon, John H. Xuereb, Catherine Foy, Luk W. Ho, Paul Hollingworth, Julie Williams, David M. A. Mann, David C. Rubinsztein, Michael John Owen, Luke Jehu, Simon Lovestone, Nicola Archer, David St Clair, Carol Brayne, John Powell |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Candidate gene Genotype Receptors Nicotinic Biology Alzheimer Disease Internal medicine Confidence Intervals Odds Ratio medicine Humans Receptor Alleles Aged Genetic association Acetylcholine receptor Chi-Square Distribution Polymorphism Genetic General Neuroscience Odds ratio medicine.disease Nicotinic acetylcholine receptor Nicotinic agonist Endocrinology Female Alzheimer's disease |
| Zdroj: | Neuroscience Letters. 358:142-146 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2004.01.016 |
| Popis: | Consistent deficits in the cholinergic system are evident in Alzheimer's disease (AD) patients, including selective loss of alpha4beta2 nicotinic acetylcholine receptors in the brains of AD patients. Knockout mice for the beta2 subunit have impaired neuronal survival in ageing. Accordingly, we have analysed polymorphisms in the genes that encode the alpha4 and beta2 subunits, CHRNA4 and CHRNB2 respectively, for genetic associations with late-onset AD. A significant association for disease was observed for a non-coding polymorphism in CHRNB2 (odds ratio=0.57, 95% confidence interval=0.35-0.95, P=0.024). Replication analysis was performed in two further sample sets. While these did not individually yield significant results, a significant association remained when all samples were pooled (odds ratio=0.70, 95% confidence interval=0.52-0.95, P=0.019). These data suggest that this variant warrants further examination in large case-control series. |
| Databáze: | OpenAIRE |
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